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Respiratory

Respiratory

14-02-2019 | Respiratory | News | Article

Sustained benefits of pirfenidone demonstrated in IPF patients

Findings from a Czech registry study suggest that pirfenidone treatment is associated with a lasting reduction in lung function decline and mortality risk among patients with idiopathic pulmonary fibrosis.

07-02-2019 | Asthma | News | Article

No benefit of antibiotic treatment for hospitalised asthma patients

Findings from a large US study suggest that early treatment with antibiotics is not associated with improved outcomes among patients hospitalised for asthma exacerbation and treated with systemic corticosteroids.

24-01-2019 | Respiratory | News | Article

Breath biomarkers could aid IPF detection

A number of exhaled biomarkers have the potential to discriminate between patients with idiopathic pulmonary fibrosis and healthy controls, but further work is needed to confirm their clinical utility, say the authors of a systematic review.

17-01-2019 | Asthma | News | Article

Better adherence with once- than twice-daily ICS/LABA therapy in asthma patients

Patients with asthma who are treated with the once-daily inhaled corticosteroid/long-acting beta agonist regimen fluticasone furoate/vilanterol have better treatment adherence than those taking the twice-daily budesonide/formoterol combination, researchers report.

14-01-2019 | Asthma | News | Article

Most patients with asthma will not experience an exacerbation

Only a third of patients with asthma will experience an exacerbation, show 7 years of observation in more than 50,000 adults with the condition.

10-01-2019 | Respiratory | News | Article

Further investigation of omeprazole warranted in patients with IPF

The proton pump inhibitor omeprazole is well tolerated and may reduce cough frequency in patients with idiopathic pulmonary fibrosis, suggest results from a pilot phase II trial.

20-12-2018 | Asthma | News | Article

Genetic variants linked to moderate-to-severe asthma susceptibility

A genome-wide association study has identified novel genetic variants associated with the risk of developing moderate-to-severe asthma, a substantial proportion of which are also associated with mild asthma susceptibility.

18-12-2018 | Asthma | News | Article

Blood eosinophil variability has treatment decision effects

Researchers have highlighted the need for blood eosinophils to be repeatedly measured in patients with severe asthma when designating treatment having found that levels vary in individuals over time.

13-12-2018 | Respiratory | News | Article

Slow gait speed predicts poor prognosis in patients with IPF

Study findings suggest that slow gait speed is significantly associated with an increased risk of mortality and hospitalisation among patients with idiopathic pulmonary fibrosis .

06-12-2018 | Asthma | News | Article

Tralokinumab does not reduce corticosteroid use in patients with severe asthma

Findings from the TROPOS trial indicate that treatment with the interleukin-13-targeted monoclonal antibody tralokinumab does not decrease corticosteroid use among patients with severe uncontrolled asthma.

29-11-2018 | Respiratory | News | Article

Support for continued pirfenidone treatment in patients with IPF progression

Patients with idiopathic pulmonary fibrosis who have previously experienced disease progression whilst receiving pirfenidone may benefit from continued treatment with the antifibrotic agent, researchers report.

22-11-2018 | Respiratory | News | Article

Inhaled hypertonic saline treatment feasible in young infants with cystic fibrosis

Preliminary findings from the phase II PRESIS trial suggest that preventative treatment with inhaled hypertonic saline is well tolerated and may improve lung clearance index in young infants with cystic fibrosis.

15-11-2018 | Chronic obstructive pulmonary disease | News | Article

BREATHE programme improves outcomes for COPD patients

An intervention combining transitional care and self-management support after hospital discharge reduces the number of subsequent hospital visits and improves health-related quality of life among patients with chronic obstructive pulmonary disease, trial findings indicate.

08-11-2018 | Respiratory | News | Article

Benefits of nintedanib extend to patients with advanced IPF

Results of a real-world study suggest that nintedanib delays lung function decline in patients with idiopathic pulmonary fibrosis irrespective of disease severity.

01-11-2018 | Asthma | News | Article

COLUMBA results support long-term use of mepolizumab in patients with severe asthma

The anti-interleukin-5 monoclonal antibody mepolizumab has durable safety and efficacy profiles over an average 3.5 years of follow-up in patients with severe eosinophilic asthma, indicate findings from the COLUMBA open-label extension study.

25-10-2018 | Respiratory | News | Article

Triple combination CFTR modulator therapy shows potential for cystic fibrosis

Combination therapy with a next-generation cystic fibrosis transmembrane conductance regulator corrector, together with tezacaftor and ivacaftor, may be a promising treatment option for cystic fibrosis, suggest findings from two studies published in The New England Journal of Medicine.

18-10-2018 | Respiratory | News | Article

TWICS results suggest no role for low-dose theophylline as add-on therapy in COPD

The addition of low-dose theophylline to inhaled corticosteroids does not reduce the risk of exacerbations among patients with chronic obstructive pulmonary disease, findings from the TWICS trial indicate.

11-10-2018 | Asthma | News | Article

Changing inhaler device does not compromise asthma treatment effectiveness

Results of a real-world study suggest that changing from a dry powder inhaler to a pressurized metered-dose inhaler is not associated with compromised treatment outcomes among patients with asthma.

04-10-2018 | Respiratory | News | Article

Aspergillus positivity in young children with CF is not associated with bronchiectasis

In 5-year-old children with cystic fibrosis, positivity for Aspergillus species in bronchoalveolar lavage cultures is associated with air trapping but not with bronchiectasis or reduced lung function, indicates a longitudinal study.

03-10-2018 | Asthma | News | Article

Systemic corticosteroids reduce blood eosinophil counts

Systemic corticosteroid treatment reduces blood eosinophil counts and low levels are maintained for weeks after treatment is discontinued, show real-world data.

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