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01-12-2016 | Interventional cardiology | News | Article

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Cardiac troponin T levels associated with mortality risk after elective PCI

medwireNews: Elevated preprocedural high-sensitivity cardiac troponin T (hs-cTnT) levels are associated with increased mortality risk among male and female patients with stable coronary artery disease undergoing percutaneous coronary intervention (PCI), results of a retrospective study suggest.

“Routine evaluation of hs-cTnT before elective PCI seems to permit risk stratification for mortality in patients during subsequent follow-up,” write Robert Byrne (Deutsches Herzzentrum München, Germany) and colleagues in the Journal of the American Heart Association.

The team found that 17.3% of 2221 patients with elevated hs-cTnT levels (more than the gender-specific 99th upper reference limit of normal) died within 3 years after PCI, compared with 3.4% of 3405 patients with normal hs-cTnT levels, a significant difference.

In multivariable adjusted models, there were more pronounced differences in mortality risk between those with high and normal hs-cTnT levels among male than female patients.

Because more than three-quarters of the study participants were male, however, the authors note that their findings “related to the effect of sex on the prognostic value of hs-cTnT should be interpreted with caution,” and conclude that “further studies are needed” to investigate this association.

By Claire Barnard

medwireNews is an independent medical news service provided by Springer Healthcare Limited. © Springer Healthcare Ltd; 2016

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