Cardiac troponin T levels associated with mortality risk after elective PCI
medwireNews: Elevated preprocedural high-sensitivity cardiac troponin T (hs-cTnT) levels are associated with increased mortality risk among male and female patients with stable coronary artery disease undergoing percutaneous coronary intervention (PCI), results of a retrospective study suggest.
“Routine evaluation of hs-cTnT before elective PCI seems to permit risk stratification for mortality in patients during subsequent follow-up,” write Robert Byrne (Deutsches Herzzentrum München, Germany) and colleagues in the Journal of the American Heart Association.
The team found that 17.3% of 2221 patients with elevated hs-cTnT levels (more than the gender-specific 99th upper reference limit of normal) died within 3 years after PCI, compared with 3.4% of 3405 patients with normal hs-cTnT levels, a significant difference.
In multivariable adjusted models, there were more pronounced differences in mortality risk between those with high and normal hs-cTnT levels among male than female patients.
Because more than three-quarters of the study participants were male, however, the authors note that their findings “related to the effect of sex on the prognostic value of hs-cTnT should be interpreted with caution,” and conclude that “further studies are needed” to investigate this association.
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