Adding the multitargeted kinase inhibitor midostaurin to standard chemotherapy prolongs survival among patients with acute myeloid leukemia and an fms-related tyrosine kinase 3 mutation, study findings indicate.
A reduced-intensity conditioning regimen offers at least equivalent 2-year relapse-free and overall survival to a myeloablative conditioning regimen before allogeneic transplantation in patients with myelodysplastic syndrome, RICMAC researchers report.
Researchers have found an association between increased abundance of a bacterial group primarily comprising Eubacterium limosum in the intestinal microbiota and a reduced risk for relapse after undergoing allogeneic hematopoietic stem cell transplantation.
Two phase 1 trials investigating the safety and efficacy of combined idelalisib, lenalidomide, and rituximab in patients with relapsed and refractory follicular and mantle cell lymphoma have been stopped early due to excessive toxicity.
Positive findings from two clinical trials have been published for the immunomodulatory agent lenalidomide in patients with heavily pretreated mantle cell lymphoma, and in adults with T-cell leukaemia–lymphoma or peripheral T-cell lymphoma.
Patients with newly diagnosed multiple myeloma receive significant progression-free and overall survival benefits from continuous treatment compared with fixed-duration therapy, suggests a pooled analysis.
A review of almost one million haematopoietic stem cell transplantation procedures has highlighted differences in the availability of the procedure and the use of autologous and allogeneic transplants across the world.
Warfarin should not be discontinued in favor of heparin before pacemaker or implantable cardioverter–defibrillator surgery in patients with a moderate-to-high risk for thromboembolism, the Bruise Control trial investigators recommend.
Cancer survivors who are treated with chest radiation are nearly twice as likely to die in the years following major heart surgery as patients undergoing similar surgery who are never treated with radiation, a study shows.