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05-12-2010 | Gynaecology | Article

Ovarian response and live birth predicted by follicle markers

Abstract

Journal abstract

MedWire News: The earliest (basal) antral follicle count (AFC), and levels of inhibin B (produced by pre-antral and early antral follicles) at day 5 of ovarian stimulation can predict ovarian response to IVF treatment, say Spanish researchers.

However, day-5 inhibin B is a superior predictor of live birth outcomes compared with AFC, they add.

"Early follicular inhibin B levels decrease during reproductive aging," explain Juan Balasch (Institut Clinic of Gynecology and Obstetrics, Barcelona) and colleagues.

"Similarly, AFC decreases during reproductive aging," they add.

To investigate the usefulness of these follicle markers in predicting ovarian response and live birth rate after IVF, the researchers calculated their sensitivity, specificity, and predictive accuracy compared with other basal variables including age, total ovarian volume, and follicle-stimulating hormone levels in 98 women.

The AFC had the best predictive value for ovarian stimulation, with an area under the receiver operating characteristic curve (AUC) score of 0.90 (where 1 denotes perfect discrimination).

In contrast, day-5 inhibin was statistically significantly more predictive of live birth rates compared with all other variables, giving an AUC score of 0.79, and a sensitivity, specificity, and prognostic reliability of 68.7, 88.5, and 81.3 percent, respectively.

MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2010

By Sarah Guy