Older paternal age does not hinder ART success
MedWire News: Systematic review results indicate that advanced paternal age does not negatively affect the outcome of assisted reproductive technologies (ART) such as IVF.
The Israeli research team looked at data from 10 studies conducted between 1990 and 2009 that assessed the effect of paternal age (ranging from ≤30 to >55 years) on ART outcomes including fertilization rate, embryo development rate, implantation rate, and pregnancy rate.
All results were adjusted for the effects of older maternal age, as older men tend to reproduce with older women, remark Martha Dirnfeld and colleagues from Carmel Medical Center in Haifa.
One study showed significantly lower fertilization rates after intracytoplasmic sperm injection for men older than 50 years versus younger men, but six studies found no such association.
Just three studies investigated or reported decreased rates of embryo implantation with advancing parental age (n = 3). However, a significant decrease in the number of blastocyst (day 5) embryos was noted in aging men overall.
Seven of 10 studies failed to find a link between paternal age and pregnancy rates, although one of the remaining three showed that the odds of pregnancy failure increased by 11 percent per year increase in age.
Dirnfeld et al cite the retrospective nature of the review as a potential limitation, highlighting that "none of the reports included high numbers of men older than 65 years."
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By Sarah Guy