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13-09-2009 | Gynaecology | Article

Intraocular pressure in postmenopausal women unrelated to estradiol levels


Journal abstract

MedWire News: Intraocular pressure (IOP) does not appear to be associated with serum estradiol concentrations in postmenopausal women, conclude Korean researchers.

Noting that women aged over 50 years have significantly higher IOPs than their male counterparts, Hee-Dong Chae and colleagues, from University of Ulsan College of Medicine in Seoul, measured serum estradiol concentrations and IOP in 8764 postmenopausal women using radioimmunoassay and Goldmann’s applanation tonometer, respectively.

The average age of the women was 59.57 years and the average duration of menopause was 7.9 years. The average serum estradiol concentration was 22.17 pg/ml, while the average IOP over both eyes was 12.23 mmHg.

Correlation analysis demonstrated that there was no significant association between IOP and age or IOP and serum estradiol concentration. Stratifying the women into four groups of estradiol concentration—≤10, 10-20, 20-30, and >30 pg/ml—revealed that there were no significant differences in IOP between the groups.

“This study does not find any correlation between serum estradiol concentration and IOP in Korean postmenopausal [women],” conclude the researchers, who note that the lower prevalence of glaucoma in Korean versus Western women may have affected the results.

MedWire ( is an independent clinical news service provided by Current Medicine Group, a part of Springer Science+Business Media. © Current Medicine Group Ltd; 2009

By Liam Davenport