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24-10-2010 | Gynaecology | Article

Endometriosis fertility index predicts likelihood of natural conception


Journal abstract

MedWire News: US researchers have developed an endometriosis fertility index (EFI) using the functional status of women's fallopian tubes, ovaries, and fimbria, to predict their chances of conceiving naturally.

"The EFI is a simple, robust, and validated clinical tool that predicts pregnancy rates for patients after endometriosis surgical staging," say G David Adamson and David Pasta, from Fertility Physicians of Northern California in Palo Alto and San Jose.

The team developed the EFI using data from 579 infertile women with endometriosis who underwent hysteroscopy for surgical staging. Women's fallopian tubes, ovaries, and fimbria were given a functional score by the surgeon.

In addition to clinical factors, patient age, years infertile, and pregnancy history-all predictive of natural conception-were accounted for while developing the EFI.

After validating the EFI in a cohort of 222 additional women with endometriosis, Adamson and Pasta found good correlation between predicted and actual outcomes for all stages of endometriosis.

Specifically, patients with an EFI of 9-10 (indicating the highest potential for natural conception) had approximate estimated pregnancy rates of 55 percent and 74 percent at 12 and 36 months, respectively, while the rates for those with the lowest EFI (0-3) remained at just 10 percent.

MedWire ( is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2010

By Sarah Guy