Depth of embryo transfer can affect IVF outcomes
MedWire News: Optimum pregnancy rates and ongoing pregnancy rates are achieved if embryos are placed at a distance of more than 10 mm from the fundal endometrial surface, Turkish researchers report.
"In addition to uterine receptivity and embryo quality, the main determinants of successful implantation are variables that influence the efficiency of embryo transfer," explain Umit Korucuoglu, from Gazi University Faculty of Medicine in Ankara, and colleagues.
The team analyzed 5,055 ultrasound-guided embryo transfers in 3,930 couples undergoing IVF to determine the influence of the depth of embryo placement on pregnancy rates.
Patients were divided into five groups according to the depth of embryo transfer, less than 10.0 mm (0.6 percent, group 1), 10.0-14.9 mm (13.4 percent, group 2), 15.0-19.9 mm (53.2 percent, group 3), 20.0-25.0 mm (25.6 percent, group 4), and more than 25.0 mm (7.2 percent, group 5).
Pregnancy rates and ongoing pregnancy rates were higher in groups 2, 3, 4, and 5 compared with group 1, at 44.9 percent, 44.2 percent, 44.2 percent, and 43.3 percent versus 32.3 percent, respectively, and the trend was the same for ongoing pregnancy rates.
Korucuoglu et al note that these trends were not significant. However, this was "most probably due to the small sample size among cycles in which embryos were replaced at a distance of less than 10 mm," they conclude.
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By Sarah Guy