Antral follicle count good predictor of cycle cancellation in COH/IUI
MedWire News: Spanish researchers have found that the antral follicle count (AFC) on the third day of a controlled ovarian hyperstimulation (COH) with intrauterine insemination (IUI) cycle is a good predictor of cancellation due to hyperresponse.
Miguel Checa (Hospital Universitari del Mar, Barcelona) and co-authors administered recombinant follicle stimulating hormone (FSH) 75 IU once-daily beginning on day 3 of the menstrual cycle to 120 women with at least 1 year of infertility undergoing COH/IUI.
Following ultrasonographic monitoring and FSH adjustments from day 10 onwards, 16 of the 120 women experienced hyperresponse and cancellation. Compared with those who completed treatment, women with cancelled cycles had significantly higher mean AFCs (19.7 vs 9.9) and ovarian volumes (15.6 vs 10.9 ml).
The researchers determined that a cut-off value of ≥16 antral follicles on day 3 of the cycle was a good predictor of hyperresponse in COH, with 100 percent sensitivity, 93.3 percent specificity, 69.6 percent positive predictive value, and 100 percent negative predictive value.
“Patients with AFC >16 may benefit with the use of protocols with lower doses, such as 37.5–50.0 IU recombinant FSH,” say Checa and team.
They add that “measuring AFC is easy to perform at the beginning of the cycle and is able to detect patients at high risk for cancellation.”
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By Ingrid Grasmo