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Genetics

Genetics

01-02-2017 | Gynaecological cancer | News | Article

TCGA analysis reveals potential cervical cancer therapeutic targets

A comprehensive genomic and molecular analysis of cervical cancers provides insight into potential therapeutic targets and identifies distinct molecular subtypes of the disease.

21-10-2016 | HBV | News | Article

HBV variants limit NA therapy response

Detectable baseline mutations in the basal core promoter and/or precore regions of hepatitis B virus are associated with a reduced likelihood of hepatitis B surface antigen loss during long-term nucleos(t)ide analogue treatment, suggest researchers.

03-10-2016 | Prostate cancer | News | Article

Prostate cancer foci genetically diverse

Molecular analysis of a single tumour sample may be insufficient to guide treatment choices in men with localised prostate cancer.

22-09-2016 | Colorectal cancer | News | Article

Adverse African–American CRC outcomes may have genetic basis

The disparity in colorectal cancer clinical outcomes between African–American patients and those of other ethnicities could be down to a panel of 15 genes.

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05-09-2016 | Prostate cancer | News | Article

HSD3B1 gene variant predicts ADT resistance

An inherited variant of HSD3B1 is a “powerful” biomarker of resistance to androgen deprivation therapy in men with castration-resistance prostate cancer, say US researchers.

14-07-2016 | Alzheimer's disease | News | Article

Genetic risk factors signal AD susceptibility in the very young

Genetic risk factors for Alzheimer’s disease appear to have an early effect on the brain and may allow the detection of susceptible young individuals before symptoms are present, findings from two studies in Neurology suggest.

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05-07-2016 | Diabetes | News | Article

Obesogenic environment magnifies genetic effect on BMI

The effect of genetic variants known to influence body mass index has been increasing over more recent years, shows a study in JAMA.

02-06-2016 | Multiple sclerosis | News | Article

HLA genetic risk burden extends to MS outcomes

Human leukocyte antigen alleles not only increase susceptibility to multiple sclerosis, but also influence the course of the disease, suggests research.

20-05-2016 | Coronary heart disease | News | Article

Novel protective gene against CAD uncovered

A large study has found that mutations in the gene encoding the major subunit of the asialoglycoprotein receptor are protective against coronary artery disease.

25-03-2016 | Parkinson's disease | News | Article

Genetic syndrome may underlie some Parkinson’s cases

Rare deletions at chromosome 22q11.2 are present at an increased rate in patients with Parkinson’s disease, researchers report in The Lancet Neurology.

18-02-2016 | Breast cancer | News | Article

Genetic test use rises in young US breast cancer patients

BRCA testing is becoming more common in women diagnosed with breast cancer by the age of 40 years in the USA, research shows, with concerns about genetic risk influencing surgical decisions.

03-02-2016 | Pulmonary hypertension | News | Article

BMPR2 gene mutations affect outcomes of PAH patients

Mutations in the bone morphogenetic protein receptor type II gene affect not only the risk of developing pulmonary arterial hypertension but also the severity and outcomes of the disease, shows a meta-analysis of individual patient data.

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02-02-2016 | Oncology | News | Article

Genetic profiling ‘feasible’ for paediatric cancer patients

Research published in JAMA Oncology demonstrates that tumour and germline molecular profiling is feasible in paediatric cancer patients and can have actionable findings.

04-11-2015 | Neurology | News | Article

Perisylvian polymicrogyria gene found

Researchers have identified the genetic basis for bilateral perisylvian polymicrogyria, the most common form of regional polymicrogyria.

17-03-2015 | Parkinson's disease | Article

Cumulative genetic risk may underlie many Parkinson’s cases

Genetic risk for Parkinson’s disease may be due as much to multiple genes with small individual effects as to single high-risk genes, research suggests.

26-01-2015 | Oncology | Article

EGFR–TKI response worse in NSCLC patients with rare EGFR gene mutations

In patients with non-small-cell lung cancer, rare epidermal growth factor receptor mutations are associated with a poorer response to EGFR–tyrosine kinase inhibitors compared with frequently occurring ones, according to a study published in Lung Cancer.

23-01-2015 | Lung cancer | Article

Plasma EGFR mutation cfDNA predicts advanced lung cancer outcome

Monitoring plasma cell-free DNA levels of epidermal growth factor receptor mutations may indicate prognosis for patients with lung adenocarcinoma after EGFR–tyrosine kinase inhibitor therapy, research suggests.

19-01-2015 | Lung cancer | Article

Rare, complex EGFR mutations adversely affect EGFR–TKI treatment outcomes

Individuals with advanced non-small-cell lung cancer who have rare or complex epidermal growth factor receptor mutations have inferior outcomes in response to EGFR–tyrosine kinase inhibitor treatment compared with those with common mutations, research indicates.

19-01-2015 | Lung cancer | Article

MET amplified in NSCLC irrespective of type, genetic background

A third of non-small-cell lung cancers show low- to high-level amplification of the MET gene, according to a German study, with no significant difference in frequency across different types of cancer and genetic backgrounds.

08-01-2015 | Oncology | Article

EGFR gene mutations, ALK gene translocations not mutually exclusive in NSCLC

Researchers from the Republic of Korea have found that epidermal growth factor receptor mutations and anaplastic lymphoma kinase translocations can occur concomitantly in a proportion of patients with non-small-cell lung cancer.