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Endocrinology and metabolism

Endocrinology and metabolism

02-03-2015 | Paediatrics | Article

Islet autoantibody levels predict progression to diabetes

Levels of insulin autoantibodies and insulinoma-associated protein 2 autoantibodies predict the onset of diabetes in young children with islet autoimmunity, show findings from the TEDDY study.

02-03-2015 | Paediatrics | Article

No adulthood metabolic consequences of central precocious puberty

Researchers have found that girls with central precocious puberty have similar metabolic and general health to other women when they reach young to middle adulthood.

02-03-2015 | Paediatrics | Article

Blunted cortisol response common in non-classic CAH

Nearly two-thirds of children with non-classic congenital adrenal hyperplasia have an inadequate cortisol response, report researchers.

29-01-2015 | Paediatrics | Article

Childhood macroprolactinomas amenable to dopamine agonist treatment

Dopamine agonist treatment normalises prolactin levels in about three-quarters of children with macroprolactinomas, show findings from a large series.

29-01-2015 | Paediatrics | Article

Postprandial glucagon linked to glycaemic control in Type 1 diabetes

Research shows that postprandial glucagon levels increase over time in children with newly diagnosed Type 1 diabetes, and are associated with worsening glycaemic control, suggesting an adjunctive treatment approach.

29-01-2015 | Paediatrics | Article

Nomogram aids management of boys with constitutional delay in growth and puberty

A puberty nomogram is better than the classical criteria for identifying boys with constitutional delay in growth and puberty, report researchers.

29-01-2015 | Paediatrics | Article

Many MEN1 tumour types found in children

Most tumour types reported in adult patients with multiple endocrine neoplasia Type-1 can be found in children with the condition, although rarely before the age of 10 years, shows a large study.

29-01-2015 | Paediatrics | Article

Genetic support for insulin system role in growth hormone response

Genetic determinants of insulin sensitivity are positively related to spontaneous growth and response to growth hormone treatment in children born small for gestational age, researchers have found.

21-12-2014 | Paediatrics | Article

‘Positive’ report of growth hormone in idiopathic short stature

US researchers report “positive” experiences with growth hormone therapy in children with idiopathic short stature.

21-12-2014 | Paediatrics | Article

Two hormones better than one for hypoglycaemia prevention with artificial pancreas

Artificial pancreas systems significantly improve glycaemic control in adolescents and adults with Type 1 diabetes, shows a head-to-head trial of single- and dual-hormone systems versus a conventional insulin pump.

21-12-2014 | Paediatrics | Article

Growth hormone boosts muscle development in Prader-Willi syndrome

Randomised trial findings show a positive effect of growth hormone therapy on muscle thickness in infants with Prader-Willi syndrome.

21-12-2014 | Paediatrics | Article

Progression to combined pituitary hormone deficiency common in IGHD

Researchers have found that a high proportion of children initially diagnosed with isolated growth hormone deficiency will progress to combined pituitary hormone deficiency.

21-12-2014 | Paediatrics | Article

Chromosome X microduplications implicated in infancy-onset gigantism

Researchers report that heritable microduplications on chromosome Xq26.3 may underlie a “striking” form of gigantism with onset in late infancy, and reveal a candidate culprit gene.

27-11-2014 | Paediatrics | Article

Inhibin B plus baseline LH levels aids hypogonadotropic hypogonadism diagnosis in boys

Researchers recommend measuring inhibin B concentration in combination with basal luteinising hormone as a first-line test to discover the underlying cause of delayed puberty in boys.

27-11-2014 | Paediatrics | Article

Congenital hypothyroidism of central origin often requires treatment

Congenital hypothyroidism of central origin should not be dismissed as a mild condition and is worth screening for, say researchers.

27-11-2014 | Paediatrics | Article

Closed-loop artificial pancreas system improves diabetes management in adolescents

Research shows that the use of an artificial pancreas system helps to compensate for omission and underestimation of insulin boluses in adolescents with Type 1 diabetes.

27-11-2014 | Paediatrics | Article

Exome sequencing refines 46,XY DSD diagnosis

Exome sequencing can identify a likely genetic cause of 46,XY disorders of sex development in about a third of cases, report researchers.

27-11-2014 | Paediatrics | Article

‘Optimal degree’ of catch-up growth defined for SGA babies

A growth trajectory in which small for gestational age babies achieve catch-up growth to a defined degree within the first few months of life appears to be best for their subsequent health, say researchers.

29-10-2014 | Paediatrics | Article

Obesity genes promote all-round increases in postnatal growth

Genetic variants that increase susceptibility to obesity are associated with increased gains in lean mass, as well as fat mass, during early childhood, meta-analysis findings indicate.

29-10-2014 | Paediatrics | Article

Hypocalcaemic seizure surveillance highlights UK public health policy failings

The occurrence of 91 confirmed or probable hypocalcaemic seizures in children with vitamin D deficiency over a 2-year period in the UK highlights a failure to promote appropriate supplementation.