Reducing abdominal obesity improves carotid IMT in Type 2 diabetics
MedWire News: Reducing abdominal obesity can slow the progression of subclinical atherosclerosis in Type 2 diabetics, suggest study results.
Accelerated atherosclerosis is common in patients with Type 2 diabetes, highlighting the importance of identifying modifiable risk factors..
Chul Woo Ahn (Yonsei University College of Medicine, Seoul, Korea) and colleagues report the results of a study of 173 patients with Type 2 diabetes who had measurements of right and left carotid intima-media thickness (IMT) - a measure of subclinical atherosclerosis - taken at baseline and after 1 year.
The researchers also measured various anthropometric and metabolic factors including glycated hemoglobin (HbA1c) and abdominal obesity, measured by waist circumference (WC) at both time points.
Ahn and co-authors found that change in WC over 1 year was positively associated with changes in HbA1c and both left and right carotid IMT over the same period.
Of note, the association with carotid IMT was found to be independent of changes in body weight, body mass index, HbA1c, and use of lipid-lowering, antiplatelet, and thiazolidinedione drugs.
Writing in the journal Obesity, Research and Clinical Practice, Ahn and team suggest: "Controlling abdominal obesity seems to have a significant impact on the progression of subclinical atherosclerosis in patients with diabetes, and therefore, more efforts should be made toward reducing WC to inhibit overt atherosclerotic diseases."
The researchers conclude that doctors should give more emphasis to the importance of lowering WC for reducing the progression of cardiovascular diseases such as atherosclerosis in patients with Type 2 diabetes.
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By Helen Albert