Adolescents with Type 2 diabetes have impaired vascular health
MedWire News: Results from a small exploratory study show that adolescents with Type 2 diabetes have significantly worse brachial artery flow-mediated dilation (FMD) and carotid intima-media thickness (IMT) than either obese or nonobese nondiabetic adolescents.
These results are similar to those of recent studies, reported on
MedWire News, showing that adolescents with Type 1 diabetes have signs of subclinical cardiovascular disease.
Louise Naylor (The University of Western Australia, Crawley) and colleagues recruited 15 obese adolescents aged 14 years with Type 2 diabetes (mean body mass index [BMI]=36.9 kg/m2), and 13 obese (mean BMI=34.2 kg/m2) and 13 lean (mean BMI=20.0 kg/m2) nondiabetic controls of a similar age.
To try and determine if the presence of Type 2 diabetes increases cardiovascular (CV) risk in children independently of obesity, the researchers measured the brachial artery FMD and carotid IMT of all the children.
As reported in the Journal of Pediatrics, they found that the adolescents with Type 2 diabetes had significantly greater carotid IMT than lean and obese controls, at 0.54 mm versus 0.46 and 0.46 mm, respectively.
Brachial artery FMD was significantly decreased in the Type 2 diabetes group, at 7.98%, versus the lean control group, at 10.40%. Obese controls had higher FMD than Type 2 diabetes patients, but the difference was not statistically significant.
"It is likely that increases in the prevalence of Type 2 diabetes mellitus in children and adolescents will translate into a rise in CV morbidity and mortality in later life," write Naylor and team.
"Future studies will need to determine whether it is possible to change the natural history of CV disease in young people with Type 2 diabetes mellitus," they suggest.
"Lifestyle interventions such as exercise, improved glycemic control, reduced blood pressure, or treatment of hyperlipidemia could all be potential approaches to improve the CV history of young people with Type 2 diabetes mellitus."
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By Helen Albert