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18-11-2009 | Diabetes | Article

Osteoprotegerin significantly elevated in Type 2 diabetic women


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MedWire News: The bone resorption inhibitor osteoprotegerin (OPG) is significantly elevated in postmenopausal women with Type 2 diabetes compared with nondiabetic controls, say researchers.

However, OPG was not associated with the metabolic syndrome, defined using the National Cholesterol Education Program–Adult Treatment Panel III criteria, or its components.

“Emerging evidence from in vitro studies and mouse genetics indicates that OPG is not merely a protective factor for bone but may, in fact, act as a protective factor for the vascular system,” say Iraj Nabipour (The Persian Gulf Tropical Medicine Research Center, Bushehr, Iran) and colleagues.

They selected 382 Iranian postmenopausal women to take part in a population-based study. Of these, 102 had Type 2 diabetes and 280 did not. Cardiovascular risk factors such as lipids and blood pressure, as well as C-reactive protein (CRP), and OPG were measured.

Nabipour et al report that women with Type 2 diabetes had significantly higher levels of OPG than nondiabetic women, at 4.33 versus 3.84 pmol/l.

Following adjustment for possible confounders such as age, CRP, and other cardiovascular risk factors, women with diabetes were 2.20-fold more likely to have higher serum levels of OPG than nondiabetics.

Interestingly, there was no significant association between mean OPG levels and the metabolic syndrome or any of its individual components.

“Thus, it still remains to be fully elucidated that observed increases in OPG in patients with Type 2 diabetes mellitus are due to insulin resistance per se,” write the authors in the journal Metabolism: Clinical and Experimental.

“Further studies are warranted to determine the pathophysiologic origin of elevated OPG in patients with Type 2 diabetes mellitus,” they conclude.

MedWire ( is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2009

By Helen Albert