Oligomenorrhea increased in girls with Type 1 diabetes with high HbA1c
MedWire News: Adolescent girls with Type 1 diabetes who have poor glycemic control are at increased risk for oligomenorrhea, show study findings.
The researchers also found that diabetic girls had later menarche and a generally higher rate of oligomenorrhea compared with nondiabetic girls.
Women with Type 1 diabetes have a higher frequency of menstrual problems than nondiabetic women, but links with glycemic control are less clear.
In this study, Anna Deltsidou (Technological Educational Institute, Lamia, Greece) and colleagues recruited 81 female adolescent Type 1 diabetics, aged 15 years on average, and 205 age-matched healthy controls.
Menstruation data were collected by questionnaire, and the investigators defined oligomenorrhea as having a menstrual cycle longer than 36 days 5/6 times in the previous year.
Girls with Type 1 diabetes had a significantly greater age at menarche compared with healthy controls, at a mean of 12.2 versus 11.7 years.
The team also found that diabetic girls were 7.8 times more likely to have oligomenorrhea compared with healthy controls.
Further analysis within the Type 1 diabetic group showed that each incidence of hypoglycemia and each 1% increase in glycated hemoglobin (HbA1c) increased the risk for oligomenorrhea 5.3 and 4.8 fold, respectively.
"Several reasons may explain the high frequency of menstrual disorders in adolescents with type 1 diabetes, such as a relative decrease in luteinizing hormone pulsatility, or delay in the appearance of the positive estrogen feedback loop on the hypothalamic-pituitary axis," write the authors in the European Journal of Obstetrics and Gynecology and Reproductive Biology.
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By Helen Albert