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14-04-2010 | Diabetes | Article

Higher vitamin D status linked to lower risk for Type 2 diabetes

Abstract

Free abstract

MedWire News: Individuals with a higher vitamin D status have a decreased risk for developing Type 2 diabetes, say researchers.

Low levels of vitamin D have been linked to an increased risk for Type 2 diabetes and cardiovascular disease in previous studies, as reported by MedWire News.

In this study, Paul Jacques (Tufts University, Boston, Massachusetts, USA) and colleagues evaluated whether vitamin D status – ie, blood levels adjusted for seasonal effects – influences subsequent risk for Type 2 diabetes.

The researchers analyzed data from a subsample (n=1972) of participants from the Framingham Offspring Study.

Predicted vitamin D status was calculated at baseline using a blood sample taken in the month of May, which was then adjusted for seasonal effects.

None of the cohort had Type 2 diabetes at baseline. After 7 years of follow-up, 133 individuals had developed the condition.

Compared with those in the lowest tertile of predicted vitamin D status, those in the highest tertile had a 40% lower incidence of Type 2 diabetes after adjustment for various confounders including age, gender, family history of diabetes, waist circumference, and serum lipids.

“Our findings advance the hypothesis that vitamin D status is inversely associated with Type 2 diabetes risk,” conclude Jacques et al in the American Journal of Clinical Nutrition.

“To further our understanding of this relation, future studies should examine the relation of long-term estimates of vitamin D status and Type 2 diabetes risk, identify the optimal vitamin D intake or 25-hydroxyvitamin D concentration associated with low risk of Type 2 diabetes, and elucidate the underlying mechanisms of the relation between vitamin D and Type 2 diabetes.”

MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2010

By Helen Albert

Literature