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30-11-2010 | Diabetes | Article

Erectile dysfunction linked to CVD risk in men with Type 2 diabetes


Free abstract

MedWire News: Results from a cohort analysis of men from the ADVANCE trial suggests that men with Type 2 diabetes who also have erectile dysfunction (ED) are at increased risk for cardiovascular disease (CVD).

ED has been previously linked with diabetes and increased CVD risk, but evidence for an increased CVD risk in men with Type 2 diabetes and ED is scarce.

Writing in the Journal of the American College of Cardiology, David Batty, University College London, UK, and colleagues report findings from an analysis of data from 6304 men, aged 55-88 years, with Type 2 diabetes who participated in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation trial (ADVANCE).

At baseline, 3158 men had ED and 3146 did not. During 5 years of follow-up, 695 deaths, and 1579 CVD, 773 coronary heart disease (CHD), 411 cerebrovascular, 58 dementia, and 1013 cognitive decline events occurred.

The team calculated that, following adjustment for various covariates such as existing illness and classic CVD risk factors, having ED at baseline was associated with a significant 19%, 35%, and 36% increased risk for CVD, CHD, and cerebrovascular events, respectively, during follow up.

Men with ED at baseline and 2 years later had the highest risk for the above three outcomes, note the authors.

These results agree with previous findings, reported by MedWire News, suggesting that men with Type 2 diabetes and ED have higher risk for cardiometabolic and CVD events than diabetics without ED.

"We demonstrated associations between ED and a range of CVD outcomes," conclude Batty et al.

"However, rather than having a direct, independent effect on CVD, it is more likely that erectile dysfunction is a marker of CVD risk," they say.

MedWire ( is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2010

By Helen Albert