‘Profound’ metabolic effects from modest weight loss in obese
medwireNews: A randomised trial published in Cell Metabolism demonstrates the “profound therapeutic effects” achievable by obese people who lose just 5% of their bodyweight.
The 19 obese, insulin-resistant participants who were randomly assigned to lose this much weight achieved multiple metabolic improvements, including lower plasma levels of glucose and insulin than the 14 assigned to maintain a stable weight. Although weight loss did not affect results of the oral glucose tolerance test, more specific tests revealed significantly improved insulin sensitivity in adipose, liver and skeletal muscle tissue.
The modest weight loss also improved insulin clearance and overall β-cell function, which Samuel Klein (Washington University School of Medicine, St Louis, Missouri, USA) and co-researchers note “have important clinical implications in preventing and treating type 2 diabetes”.
Progressive weight loss enhanced these metabolic benefits, they add.
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