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21-07-2011 | Diabetes | Article

Effects of Angiopoietin-2, soluble Tie-2 molecules in diabetes clarified


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MedWire News: Researchers report that angiopoietin-2 (Ang-2) and soluble Tie-2 (sTie-2) levels may indicate metabolic control and risk for disease complications in patients with Type 2 diabetes.

Alexandra Kautzky-Willer (Medical University of Vienna, Austria) and team explain: "Circulating Ang-2 could serve as a new marker of oxidative stress and vasculopathy while sTie-2 seems to primarily reflect long-term metabolic control in advanced Type 2 diabetes."

The researchers obtained blood and urine samples from 80 patients with a mean diabetic history of 15 years and a mean age of 65 years. Ang-2 and sTie-2 levels were measured among all patients, and the presence of diabetic complications was assessed.

Writing in the journal Cardiovascular Diabetology, Kautzky-Willer and co-investigators report that Ang-2 levels were associated with several markers of diabetic complications, such as diastolic blood pressure, plasma insulin, homeostasis model assessment of insulin resistance (HOMA-IR), creatinine, glomerular filtration rate (GFR), and gamma-glutamyl transferase (GGT).

These associations persisted even after adjustment for the effects of age and body mass index (BMI).

In addition, patients with macrovascular diabetic complications, a requirement for insulin therapy, and polyneuropathy, had significantly higher Ang-2 levels than those without.

Although Ang-2 levels showed a positive correlation with sTie-2 levels, levels of the latter were not associated with the presence of diabetic complications, say Kautzky-Willer et al.

Instead, sTie levels were significantly associated with glycemic parameters, namely glycated hemoglobin (HbA1c), fasting plasma glucose, insulin, and markers of liver function.

Serum GGT levels were found to independently predict levels of circulating Ang-2 in Type 2 diabetic subjects, report the researchers. They add that as serum GGT level is a presumed marker of oxidative stress, this GGT-Ang-2 relationship could explain the association of Type 2 diabetes and Ang-2.

However, Kautzky-Willer and team say that they remain unsure of the mechanism by which sTie-2 reflects metabolic control in diabetic patients.

MedWire ( is an independent clinical news service provided by Springer Healthcare Limited. © Springer Healthcare Ltd; 2011

By Lauretta Ihonor