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09-05-2011 | Diabetes | Article

Diabetes moderate, but significant contributor to CHD event risk in Japan

Abstract

Free abstract

MedWire News: Diabetes and elevated glucose levels increase the risk for incident coronary heart disease (CHD) in the Japanese population, say researchers.

These findings agree with those from previous epidemiological studies in different ethnic populations showing an increased risk for CHD in patients with diabetes.

As research on links between diabetes and CHD in Japanese individuals is lacking, mainly due to the very low prevalence of the disease in people of this ethnic group/ethnicity, Isao Saito (Ehime University Graduate School of Medicine, Toon City, Japan) and co-workers followed up 31,192 individuals between 40 and 69 years of age to evaluate associations between baseline diabetes status and incident CHD.

In total, 25,192 individuals were normoglycemic, 4744 were prediabetic or had borderline diabetes (fasting plasma glucose [FPG] 5.6-6.9 mmol/l), and 1256 had Type 2 diabetes (FPG at or above 7.0 mmol/l) at baseline. None of the participants had a prior history of CHD or cancer.

During a mean follow-up period of 12.9 years 266 CHD events occurred (suspected/actual myocardial infarction or sudden cardiac death).

Using normoglycemic participants as controls, patients with prediabetes or diabetes were a significant 1.65- and 3.05-fold more likely to experience incident CHD, respectively, compared with controls. This association was still valid after adjustment for gender, age, study community, fasting, and other conventional risk factors.

The researchers note that the increase in risk for CHD in patients with diabetes was independent of whether or what type of medication they were taking for their condition.

Saito and team estimated that the fraction of the risk for CHD events that could be attributed to prediabetes or diabetes in this cohort was moderate, at 6.9% and 6.3%, respectively. They say that these figures are similar to the risk for CHD previously attributed to the metabolic syndrome in Japanese people.

The results of this study are published in the journal Atherosclerosis.

MedWire (www.medwire-news.md) is an independent clinical news service provided by Springer Healthcare Limited. © Springer Healthcare Ltd; 2011

By Helen Albert