medwireNews: A small study suggests that the vasodilation effects of aspirin may be delayed in people with type 2 diabetes, and may wear off faster than in people without the condition.
When tested 1 hour after taking 75 mg aspirin, endothelium-dependent vasodilation had not changed in the 21 study participants who had type 2 diabetes, whereas it had significantly increased in 21 age- and sex-matched control participants without diabetes.
After 6 days of taking once-daily aspirin, both groups had significant improvements in vasodilation 1 hour after dosing, but whereas this lasted for 24 hours in the control group, it wore off in the diabetes group, to be not significantly different from that before they started taking aspirin.
“This may represent an early sign of endothelial dysfunction in people with diabetes, because we observed no differences between the groups in terms of endothelial function at baseline,” write Liv Vernstrøm (Aarhus University, Denmark) and co-researchers in Diabetic Medicine.
“Our results might also indicate that people with diabetes may benefit from an alternate dosing regimen, perhaps twice-daily dosing, which has been suggested previously.”
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