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  • rhGH therapy does not impact lifetime IGF-1 exposure in SGA children

  • PEGylated weekly rhGH promising in idiopathic short stature

  • Somatropin safety and efficacy confirmed for childhood growth disorders

Pituitary-targeting seliciclib may warrant further investigation for Cushing’s disease

Two phase 2 studies published in The Journal of Clinical Endocrinology & Metabolism in October 2022 suggest that seliciclib, a selective cyclin-dependent kinase inhibitor targeting pituitary adrenocorticotropic 2 hormone production, may improve hypercortisolemia in patients with Cushing’s disease.

Extension study points to ‘considerable long-term benefits’ of osilodrostat

The LINC 3 extension study, by Maria Fleseriu and team, suggests that long-term treatment with osilodrostat is associated with sustained benefits for people with Cushing’s disease.