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18-08-2011 | Dermatology | Article

Terbafine spray effectively decontaminates shoes exposed to T. Rubrum

Abstract

Free abstract

MedWire News: Study findings show that a single application of terbafine 1% spray powder or solution successfully decontaminates shoe insoles colonized by Trichophyton rubrum, the dermatophyte responsible for the majority of athlete's foot and fungal nail infections.

Martine Feuilhade de Chauvin from Denis Diderot University in Paris, France, tested the efficacy of two formulations (powder or solution spray) of terbafine 1% for decontamination of three types of commonly used shoe insoles (everyday shoes, trainers, and slippers).

Prior to spraying with terbafine, the six insoles were colonized with T. Rubrum through dispersal of 0.5 g of infected skin scales onto each insole after premoistening with sterile saline to mimic sweat exposure. They were then re-humidified with normal sterile saline and left in separate cardboard boxes for 48 hours before being treated with powder or solution terbafine spray.

Three control insoles were also colonized for comparison purposes and did not undergo treatment with terbafine.

Samples were scraped off all of the insoles at 48 and 96 hours after the terbafine sprays were applied. These were placed in Sabouraud agar, incubated at 27°C, and examined 3 and 6 weeks later.

Feuilhade de Chauvin found that while all three control insoles had numerous T. Rubrum colonies at 3 and 6 weeks, all six of the treated insoles remained sterile with no colonies at both time points

"This study, carried out in a real-life situation for the first time, has clearly shown that it is possible to successfully treat the insoles of shoes or slippers which are colonized by the scales of skin infected with T. rubrum," writes Feuilhade de Chauvin in the Journal of the European Academy of Dermatology and Venereology.

"The antifungal treatment of shoes worn with bare feet, which we have until now advocated based on an empirical approach, has now been shown to be necessary," she says.

"Patients are therefore advised to decontaminate the insoles of all shoes or slippers worn with bare feet."

MedWire (www.medwire-news.md) is an independent clinical news service provided by Springer Healthcare Limited. © Springer Healthcare Ltd; 2011

By Helen Albert