Skip to main content

Colorectal cancer

Colorectal cancer

Molecule of DNA forming inside the test tube in the blood test equipment 3d rendering

28-07-2022 | Oncology | Highlight | Article

ctDNA analysis can detect KRAS G12C mutations in people with cancer

A large US study has shown the feasibility of circulating tumor DNA analysis to detect KRAS G12C mutations in patients with solid tumors.

abstract world map

11-07-2022 | Oncology | News | Article

Cancer screening declined globally during COVID-19 pandemic

A systematic review and meta-analysis has identified global decreases in breast, cervical, and colorectal cancer screening during the early phase of the COVID-19 pandemic.

USA outline_flag

12-05-2021 | Oncology | News | Article

COVID-19 leaves large cancer screening deficit in USA

Breast, prostate, and colorectal cancer screening rates declined sharply during the initial months of the COVID-19 pandemic in the USA, and while they subsequently recovered, a large deficit remains, study findings indicate.

13-04-2021 | Oncology | News | Article

Mechanisms of resistance to KRAS G12C inhibition characterized

US researchers have identified diverse molecular and histologic mechanisms of acquired resistance to KRAS G12C inhibitors in people with cancer.

31-03-2021 | Oncology | News | Article

Worse cancer outcomes in areas of deprivation transcend access to quality care

Researchers have identified an association between socioeconomic deprivation and poor survival in people with cancer participating in clinical trials.

Man receiving radiotherapy

14-01-2021 | Oncology | News | Article

Real-world data support efficacy of SABR for extracranial oligometastases

The beneficial survival outcomes and low toxicity associated with stereotactic ablative body radiotherapy in patients with extracranial oligometastases persist in the real-world setting.

26-11-2020 | Oncology | News | Article

Oligometastatic cancer outcomes acceptable with SABR

Stereotactic ablative radiotherapy is associated with “clinically acceptable” rates of toxicity, local control, progression-free survival, and overall survival in people with oligometastatic cancer, meta-analysis data suggest.

12-03-2020 | Oncology | News | Article

Metastases progression linked to deteriorating HRQoL

Disease progression among patients with metastatic lung, pancreatic, colorectal, and breast cancer is associated with statistically significant and clinically relevant reductions in health-related quality of life, real-world study data show.

23-04-2019 | Oncology | News | Article

SABR may improve survival in oligometastatic cancer

The phase II SABR-COMET study has indicated that stereotactic ablative radiotherapy prolongs overall and progression-free survival versus palliative treatment in patients with up to five oligometastases.

01-02-2019 | Colorectal cancer | News | Article

EMA gives biosimilar bevacizumab positive opinion

Read more on this decision here

29-11-2018 | Colorectal cancer | News | Article

Rechallenge with cetuximab, irinotecan may benefit mCRC patients

Approximately one-fifth of patients with RAS and BRAF wild-type metastatic colorectal cancer derive clinical benefit from rechallenge with cetuximab plus irinotecan, Italian researchers report.

06-11-2018 | Oncology | Main feed | News

Run-in period may improve adherence to aspirin for chemoprevention

In patients undergoing radical therapy for cancer, an 8-week run-in period of aspirin is acceptable and well tolerated, and could reduce the risk for nonadherence and participant attrition in adjuvant and prevention trials, say researchers.

11-10-2018 | Oncology | Main feed | News

Screen-detected colon cancer patients experience fewer complications

Patients whose colon cancers are detected by routine screening have fewer postoperative complications than individuals whose cancers are diagnosed outside of a national programme, study findings indicate.

01-08-2018 | Oncology | News | Article

Benefits of laparoscopic surgery for colorectal liver metastases highlighted

Minimally invasive liver surgery is associated with less postoperative morbidity, fewer major complications, and shorter hospital stays than open surgery among patients with colorectal liver metastases, Italian researchers report.

03-07-2018 | Colorectal cancer | Main feed | News

Fruquintinib prolongs metastatic CRC survival

Phase III trial results indicate that third- or later-line treatment with fruquintinib leads to significantly improved overall survival in Chinese patients with metastatic colorectal cancer.

29-06-2018 | Colorectal cancer | News | Article

In other news: CRC and surveillance

We cover three studies of colorectal cancer surveillance, one evaluating the relationship between adenomas at colonoscopy and the long-term incidence of cancer, while the other two investigate whether higher-intensity post-surgery follow-up improves outcomes.

HIPEC surgery

14-06-2018 | Colorectal cancer | News | Article

Oxaliplatin HIPEC unnecessary for colorectal peritoneal carcinomatosis patients

Oxaliplatin-based hyperthermic intraperitoneal chemotherapy after cytoreductive surgery does not improve the survival of colorectal cancer patients with peritoneal carcinomatosis, the PRODIGE 7 investigators report.

02-06-2018 | Colorectal cancer | News | Article

Metastatic CRC cost disparity revealed for USA, Canada

The cost of metastatic colorectal cancer treatment in the USA is significantly more expensive than in Canada but does not achieve a greater survival benefit among patients, highlight findings reported at the ASCO Annual Meeting 2018 in Chicago, Illinois, USA.

29-05-2018 | Colorectal cancer | News | Article

Sex differences highlighted for CRC chemotherapy-related toxicity

Women have an increased risk for adverse events associated with fluorouracil-based chemotherapy for colorectal cancer, suggests an analysis of the PETACC-3 trial.

25-05-2018 | Colorectal cancer | News | Article

Worse prognosis for patients with V600E BRAF-mutated colorectal liver metastases

The presence of the BRAF V600E mutation in colorectal liver metastases is associated with a worse prognosis and increased risk for recurrence, according to findings from an international retrospective cohort study.