Sagittal abdominal diameter associated with atherogenic lipoprotein subfractions
MedWire News: Sagittal abdominal diameter (SAD) is more strongly associated with atherogenic lipoprotein subfractions than is waist circumference in middle-aged White and Japanese men, study findings suggest.
Researchers found that SAD, which they describe as the height of the abdomen when lying in a supine position (ie, the anterioposterior diameter), had a stronger relationship with concentrations of large very low-density lipoprotein (LDL), total and small LDL, and large high-density lipoprotein (HDL) particles than did waist circumference.
Both anthropometric measures of abdominal adipose tissues correlated with visceral adipose tissue, although waist circumference but not SAD significantly explained levels of subcutaneous adipose tissue.
Jina Choo (Korea University, Seoul, South Korea) and colleagues studied information on 260 White men in the USA and 282 Japanese men in Japan, who were aged 40 to 49 years without cardiovascular disease or diabetes.
The men's visceral and subcutaneous adipose tissue was assessed by computed tomography, SAD by a portable sliding-beam caliper, and waist circumference with a measuring tape. Lipoprotein subfractions were determined by nuclear magnetic resonance spectroscopy.
Both SAD and waist circumference were significantly and positively associated with large very LDL and total and small LDL particle levels, and inversely associated with large HDL particle concentration in White and Japanese men.
After adjusting for body mass index (BMI), the significant associations of SAD remained in both groups but those for waist circumference lost significance in White men.
When SAD and waist circumference were simultaneously included into BMI-adjusted models, the associations of SAD were not only significant but also statistically stronger than those of waist circumference for both White and Japanese men, the researchers note.
In addition, the pattern of SAD associations with these lipoprotein subfractions was comparable to that of the associations with visceral adipose tissue.
Writing in the journal Metabolism: Clinical and Experimental, the researchers suggest: "To identify high-risk abdominally visceral obese individuals linked with elevated atherogenic lipoprotein subfractions, SAD may be a better measure than waist circumference across White and Japanese men."
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By Anita Wilkinson