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31-03-2010 | Cardiometabolic | Article

Adipokine profile ‘useful’ for treating obesity in children

Abstract

Free abstract

MedWire News: Measuring serum adipokine levels can provide useful information on the treatment of obesity in children, Spanish researchers say.

The team found evidence to suggest that the maturational stage of adipose tissue exerts a detrimental influence on the serum adipokine profile in obese children.

Levels of leptin, leptin soluble receptor (sOB-R), and total and high-molecular-weight (HMW) adiponectin, better reflected body fat changes than the proinflammatory molecules resistin, interleukin (IL-)6, and tumor necrosis factor (TNF)-α.

Jesús Argente (Universidad Autónoma de Madrid) and colleagues studied the influence of weight reduction on total and HMW adiponectin in 70 prepubertal, obese White children over an 18-month period.

Treatment for obesity included behavioral treatment, physical activity, and changing eating habits.

Overall, 51 children were assessed after reducing their body mass index (BMI) by one standard deviation score (SDS), 21 were assessed following a reduction of two SDSs, and 44 children were studied at 6 months after reducing their BMI by one SDS.

At diagnosis, obese children had significantly higher total adiponectin and lower HMW-adiponectin levels than did 61 control children with a normal BMI.

Body fat reduction significantly increased total and HMW adiponectin and sOB-R levels, and decreased leptin and IL-6 levels.

After 6 months of sustained weight reduction among the obese children there was a decrease in TNF-α, whereas regaining over 0.5 SDS in BMI increased leptin and decreased total adiponectin.

HMW adiponectin levels correlated negatively with homeostasis model assessment (HOMA) index and BMI in the whole cohort, and also with total adiponectin levels and HOMA index in obese children.

However, neither total nor HMW adiponectin correlated with body fat content in the obese children.

Reporting in the journal Obesity, the researchers say: “Taken together these results suggest that longitudinal evaluation of the serum adipokine profile and particularly [total] and HMW adiponectin levels affords useful information for the treatment and follow-up of obesity and its related comorbidities in prepubertal [obese] children.”

MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a part of Springer Science+Business Media. © Current Medicine Group Ltd; 2010

By Anita Wilkinson

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