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03-02-2010 | Cardiometabolic | Article

Lifestyle intervention program improves global CV risk profile


Free abstract

MedWire News: A structured comprehensive lifestyle intervention program is effective for improving anthropometric and lipid measures in overweight patients with hypercholesterolemia, research suggests.

The researchers say the program, abbreviated to “CLIP”, may prove helpful for managing patients’ overall cardiovascular (CV) risk, although the sustainability of the benefits need to be confirmed in future studies.

Xenia Cleanthous (Heart Foundation, Melbourne, Australia) and team undertook a pilot study to evaluate the efficacy of CLIP – a structured, omnivorous, energy-restricted eating pattern combined with a structured exercise program – compared with qualitative lifestyle advice (ie, provision of standard advice on eating and physical activity) or qualitative lifestyle advice plus simvastatin therapy. In all, 65 adults aged 20–69 years who were overweight or obese (body mass index 27–40 kg/m2) and had hypercholesterolemia were enrolled and randomly assigned to one of the three interventions.

The CLIP menu plan provided 6500 kJ of energy (protein 20%, fat 35%, carbohydrate 40%) and featured both conventional and functional foods. CLIP participants attended fortnightly individual counseling sessions with a qualified dietician, completed food diaries each day, and were supplied with key foods to encourage compliance.

At the end of the 6-week study period, the CLIP group had significantly greater reductions in weight and waist circumference (5% and 5%, respectively) than the other groups (1% and 3%, respectively, in both lifestyle and lifestyle plus statin groups).

Levels of total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol fell by 15% and 13%, respectively, in the CLIP group, and by 37% and 26%, respectively, in the lifestyle plus statin group.

Glucose and insulin levels fell in the CLIP group but were relatively unchanged in the other two groups, whereas beta-carotene levels and blood pressure were unchanged in all three groups over the study period.

Cleanthous and co-authors say that, although the structured intervention was not as effective in lowering LDL cholesterol as simvastatin, it was associated with improvements in several other cardiovascular risk factors.

“These data support that integrating several key food components into a weight-loss program to maximize improvements in blood lipid profile will therefore also produce benefits for cardiovascular health,” they write in the journal Nutrition, Metabolism, and Cardiovascular Diseases.

They add: “Primary prevention of cardiovascular disease with lifestyle modification employing a structured approach, such as CLIP, may delay the need for pharmaceutical management of risk factors or potentially reduce the dosage needed to achieve treatment targets.”

MedWire ( is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2010

By Joanna Lyford