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03-03-2011 | Cardiometabolic | Article

Link between dyslipidemia and lichen planus confirmed

Abstract

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MedWire News: Patients with lichen planus (LP) are more likely to have dyslipidemia than people without the condition, show results from a case-control study.

These results confirm those of another study, previously reported by MedWire News, that show evidence of a link between the two conditions.

Salvador Arias-Santiago (Granada University, Spain) and colleagues recruited 80 patients with LP and 80 controls without LP who were being treated for other dermatologic conditions such as nevi, seborrheic keratosis, actinic keratosis, or verruca. They assessed their triglyceride, total, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) cholesterol levels.

To avoid possible confounding, for example by having an effect on lipid levels, patients with lichenoid drug eruption and those who were being treated for LP with systemic corticosteroids, retinoic acid, or methotrexate, were excluded from the study.

The team found that patients with LP had significantly higher levels of triglycerides (145.9 versus 101.5 mg/dl) total cholesterol (197.7 versus 178.4 mg/dl) and LDL cholesterol (120.8 versus 100.9 mg/dl) than the control patients.

In addition, the LP patients also had significantly lower levels of HDL cholesterol than the controls, at 55.3 versus 61.9 mg/dl. <

Psoriasis has also been associated with an increased risk for dyslipidemia, and the researchers believe that the inflammatory nature of both psoriasis and LP may explain the link.

Arias-Santiago and team say that if the relationship between LP and dyslipidemia is confirmed in additional studies, "it may be prudent to follow-up patients with LP for the development of cardiovascular risk factors to permit an earlier diagnosis of an unknown dyslipidemia and initiation of appropriate treatment."

The results of this study are published in the Journal of the European Academy of Dermatology and Venereology.

MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2011

By Helen Albert

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