Chronic inflammation may explain dyslipidemia in lichen planus patients
MedWire News: The high frequency of dyslipidemia among patients with lichen planus may be due, at least in part, to chronic inflammation, say researchers.
Salvador Arias-Santiago (Granada University, Spain) and colleagues carried out a case-control study of 200 men and women, 100 with lichen planus and 100 without the skin condition, who consecutively attended a dermatology outpatient clinic in Granada.
As observed in previous studies reported by MedWire News, the team found that the individuals with lichen planus had significantly higher levels of various lipids than controls, including low-density lipoprotein (LDL; 120.1 vs 103.9 mg/dl) and total cholesterol (200.1 vs 183.4 mg/dl), as well as the total-to-high-density lipoprotein (HDL) cholesterol (3.7 vs 2.9) and LDL-to-HDL ratio (2.2 vs 1.6).
They calculated that patients with lichen planus were 2.85 times more likely to have dyslipidemia than controls, following adjustment for factors including age, gender, and body mass index.
To assess possible reasons for this, Arias-Santiago and team evaluated anthropometric characteristics and various inflammatory and metabolic biomarkers in patients with lichen planus and controls.
They found no significant differences in levels of glucose, prevalence of abdominal obesity, or blood pressure between the two groups.
However, C-reactive protein levels, erythrocyte sedimentation rate, and fibrinogen levels were significantly higher in patients with lichen planus than in controls, at 0.53 versus 0.31 mg/dl, 14.2 versus 9.9 mm/h, and 357.9 versus 305.1 mg/dl, respectively.
"Chronic inflammation in patients with lichen planus may explain the association with dyslipidemia," write Arias-Santiago and co-authors in the American Journal of Medicine.
"Lipid levels screening in men or women with lichen planus may be useful to detect individuals at risk and start preventive treatment against the development of cardiovascular disease," they suggest.
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By Helen Albert