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08-06-2010 | Cardiometabolic | Article

CIMT reference data published for Andean-Hispanics

Abstract

Free abstract

MedWire News: Researchers have defined ethnic-specific cutoffs of carotid artery intima-media thickness (CIMT) and correlates of subclinical atherosclerosis in an Andean-Hispanic population.

They say that their data in indigenous people from Peru mirror those of other populations and can be used to identify Andean-Hispanics at increased risk for atherosclerotic vascular disease.

Notably, neither C-reactive protein nor high-density lipoprotein cholesterol was associated with CIMT or carotid plaque in this population.

Josefina Medina-Lezama (Santa Maria Research Institute, Arequipa, Peru) and colleagues investigated CIMT among participants in the PREVENCION study, a population-based cohort of 1448 adults living in a large city in Peru. The predominant ethnicity is Andean-Amerindian mestizo (ie, admixed indigenous Quechua and Aymara) and the mean age was 52.4 years.

The mean CIMT, assessed using high-resolution B-mode carotid ultrasonography, was 0.63 mm in men and 0.57 mm in women, a significant difference. CIMT was significantly correlated with increasing age in both genders.

Mean CIMT in participants aged 20–29, 30–39, 40–49, 50–59, 60–69, and 70–80 years was 0.50, 0.52, 0.58, 0.63, 0.68, and 0.76 mm, respectively.

The 95th percentiles in these age groups were 0.67, 0.67, 0.75, 0.82, 0.81, and 0.98 mm, respectively, in men and 0.58, 0.61, 0.69, 0.76, 0.86, and 0.91 mm, respectively, in women.

Significant independent predictors of higher CIMT were older age, systolic blood pressure, diabetes mellitus, impaired fasting glucose, and low-density lipoprotein.

As their study showed a direct association between CIMT and increasing age, even in healthy individuals, the researchers conclude: “Our normative data can be used to estimate the ‘arterial age’ of individual subjects by comparing individual measurements with the percentile distributions described herein.

“This is an intuitive and promising approach for risk stratification, which requires further validation.”

The study is published in the journal Atherosclerosis.

MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2010

By Joanna Lyford