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07-03-2017 | Public health | Highlight | Article

Diet associated with ‘substantial proportion’ of cardiometabolic deaths

Research published in JAMA suggests that suboptimal intake of specific dietary factors is associated with almost half of deaths from heart disease, stroke, or type 2 diabetes in the USA.

05-10-2016 | Cardiometabolic | News | Article

More genetic evidence ties low lipids to diabetes risk

A meta-analysis published in JAMA shows that mutations linked to reduced low-density lipoprotein cholesterol levels are associated with an increased risk of diabetes.

27-09-2016 | Cardiometabolic | News | Article

Statin, some nonstatin lipid-lowering therapies broadly equivalent

Nonstatin therapies that act via upregulation of the low-density lipoprotein receptor prevent major vascular events as effectively as statins do, shows an analysis in JAMA.

25-08-2016 | Cardiometabolic | News | Article

CAC score may refine statin use in elderly

Noninvasive imaging identifies patients who can be spared statin therapy despite advanced age, shows an analysis of the BioImage cohort.

17-08-2016 | Cardiometabolic | News | Article

PCSK9 inhibitors not cost-effective at current prices

Proprotein convertase subtilisin/kexin type 9 inhibitors are not currently cost effective for the prevention of cardiovascular events in patients with familial hypercholesterolemia or atherosclerotic cardiovascular disease, US research shows.

10-08-2016 | Cardiometabolic | News | Article

Insufficient evidence for lipid disorder screening in under 20s

There is insufficient evidence to assess the balance of benefits and harms of screening for lipid disorders in children and adolescents, concludes a recommendation statement from the US Preventive Services Task Force.

05-08-2016 | Diabetes | News | Article

Low diabetes risk from medium-term PCSK9 inhibition

Pooled data from the ODYSSEY phase III trials show that PCSK9 inhibition does not result in excess cases of new-onset diabetes during up to 18 months of treatment, despite mounting evidence that lowering cholesterol levels increases diabetes risk.

05-08-2016 | Cardiometabolic | News | Article

Lipid levels have opposing effects on risk of diabetes, CAD

Findings from a Mendelian randomisation study suggest that lifelong exposure to increased levels of the major lipid fractions is protective against Type 2 diabetes, even as it raises the risk of coronary artery disease.

04-08-2016 | Cardiometabolic | News | Article

Clinical FH criteria flag high-risk ACS patients

Patients with acute coronary syndromes have a more than doubled risk of recurrent coronary events within the subsequent year if they meet clinical criteria for familial hypercholesterolaemia, research shows.

02-08-2016 | Cardiometabolic | News | Article

Statin benefits dependent on baseline kidney function

The benefits of statin-based treatments among patients with chronic kidney disease diminish with decreasing estimated glomerular filtration rate, with little evidence of any benefit for patients on dialysis, results of a large meta-analysis show.

22-07-2016 | Cardiometabolic | News | Article

LDL cholesterol variability has adverse neurocognitive effects

High variability in low-density-lipoprotein cholesterol levels between visits is associated with poor cognitive performance, researchers report.

14-07-2016 | Cardiometabolic | News | Article

Statin primary prevention effect in FH quantified

A retrospective analysis suggests that statin therapy reduces the risk of a first coronary artery disease event or death in patients with familial hypercholesterolaemia by around 44%.

04-07-2016 | Cardiometabolic | News | Article

Accelerated cardiovascular risk in patients with FH phenotype

Patients with levels of low-density lipoprotein cholesterol normally seen in familial hypercholesterolaemia have the cardiovascular risk of someone decades older than they are, shows a population-based study.

21-06-2016 | Cardiometabolic | News | Article

Real-world analysis questions very low LDL targets

Patients treated for hypercholesterolaemia in clinical practice may not derive additional benefit from very intensive statin treatment, say researchers.

19-05-2016 | Cardiometabolic | News | Article

Raised lipoprotein(a) could account for a quarter of FH cases

High levels of lipoprotein(a) could account for a substantial proportion of cases of familial hypercholesterolaemia, a large study shows.

19-08-2013 | Cardiometabolic | Article

Statins could be ‘novel therapy for asthma’

Researchers from the USA say that there may be certain patients with asthma who could benefit from the addition of statins to their inhaler therapy.

16-06-2013 | Cardiology | Article

Mixed success for hypertension treatment algorithm

An algorithm for treating primary care patients with hypertension and dyslipidemia may help to reduce blood pressure, shows a randomized trial.

28-04-2013 | Cardiology | Article

Hypertensive patients may need firm dietary advice

People who have dyslipidemia or are overweight adopt healthier diets than those without, whereas patients with hypertension persist with some unhealthy eating patterns, study results show.

21-04-2013 | Metabolism | Article

Orlistat liver injury link questioned

Researchers have found that users of the obesity drug, orlistat, have an increased risk for acute liver injury compared with non-users in the time period prior to taking the drug.

04-04-2013 | Cardiometabolic | Article

Statins ‘commonly stopped, restarted’

The factors that influence compliance with statin therapy are complex, with high rates of statin discontinuation yet also high long-term tolerance when rechallenged, shows research.