VTE characterized in Asian lymphoma patients
MedWire News: The incidence of venous thromboembolism (VTE) in Asian populations is similar to that of Western countries, say researchers who identified the risk factors and clinical features of VTE in lymphoma patients.
"VTE was associated with chemotherapy, brain involvement, and age," report Seok Jin Kim (Sungkyunkwan University, South Korea) and authors in Thrombosis Research.
To date, most data regarding VTE have come from retrospective studies done in Western countries, explain the researchers They therefore analyzed VTE, defined as any case of pulmonary embolism and/or deep vein thrombosis, in 686 Asian patients who were enrolled in the Samsung Medical Center Lymphoma Cohort Study.
All patients were newly diagnosed with Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL). The median follow-up period was 21.8 months.
Overall, 54 cases of VTE occurred, including 33 cases of deep vein thrombosis (61.1%) and 21 cases of pulmonary embolism (38.9%).
The median time between the diagnosis of lymphoma and the occurrence of VTE was 1.97 months and the 1-year actuarial incidence was 7.9%.
The incidence of VTE was similar in patients who had NHL and HL. The incidence of VTE was significantly higher in patients who received chemotherapy than in those who did not (p=0.002).
Multivariate analysis revealed that being older than 60 years and brain involvement were independently associated with an increased risk for VTE, at respective odds ratios of 2.29 and 4.19 (p<0.05).
Among the 54 patients with VTE, 14 (25.9%) patients died, however no VTE-related deaths were noted, say the authors. Therefore, the overall survival of patients with VTE was not significantly difference from that of patients without VTE.
"VTE was manageable and the impact of VTE on survival outcome was not demonstrated in this study population," they remark.
"These results may help better understand VTE in lymphoma patients from Asian as well as Western countries."
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By Piriya Mahendra