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18-08-2011 | Cardiology | Article

Pregnancy related DVT impacts future quality of life

Abstract

Free abstract

MedWire News: Women with pregnancy-related deep vein thrombosis (DVT) report worse long-term quality of life (QoL) than women who do not develop the condition during pregnancy, study findings indicate.

The results arise from a case-control study in which researchers assessed disease-specific QoL and symptom severity (Sym) using the Venous Insufficiency Epidemiological and Economic Study (VEINES)-QoL/Sym questionnaire.

The researchers explain that the VEINES-QoL/Sym comprises 26 items that measure leg symptoms, limitations in daily activity, and psychological impact of the symptoms during the previous 4 weeks.

In total, 208 women with validated pregnancy-related DVT, and 347 women who gave birth at the same time but did not develop DVT (controls), completed the questionnaire.

The researchers found that the women who developed pregnancy-related DVT had significantly lower mean VEINES-QoL and VEINES-Sym scores than controls, at 45.6 and 45.4 versus 52.8 and 52.7, respectively.

In addition, women with a history of pregnancy-related DVT were between five and six times more likely than controls to have VEINES-QoL/Sym scores below the 25th percentile than controls, even after adjustment for potential confounders such as age, marital status, income, and musculoskeletal symptoms.

Per Morten Sandset (Oslo University Hospital, Norway) and colleagues note that socioeconomic factors may influence QoL scores, but little is known about the impact of such factors on VEINES-QoL/Sym scores.

They therefore conducted a multivariable analysis to identify factors that may affect the VEINES-QoL/Sym scores. They found that a low education (High school or less) was an independent predictor for both low VEINES-QoL and VEINES-Sym scores (<25th percentile), while being married/cohabitated predicted low VEINES-Sym scores.

Sanset and co-authors conclude that their findings "supports the use of the VEINES-QoL/Sym in follow-up studies of pregnancy-related DVT, even though scores also seem to be influenced by education and marital status."

The study data appear in the Journal of Thrombosis and Haemostasis.

MedWire (www.medwire-news.md) is an independent clinical news service provided by Springer Healthcare Limited. © Springer Healthcare Ltd; 2011

By Laura Dean

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