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23-05-2012 | Cardiology | Article

Experts MASTER mortality predictors in thrombosis patients


Free abstract

MedWire News: An analysis of the MASTER registry has shown that cancer, ileo-caval thrombosis, long-term heparin treatment, and in-hospital management are associated with increased mortality in thrombosis patients.

In addition, in-hospital management and male gender were associated with an increased risk for venous thromboembolism (VTE) recurrence.

"The aim of this multicenter registry was to prospectively assess the long-term clinical outcome in a cohort of unselected patients with objectively confirmed acute VTE," write Melina Verso (Università di Perugia, Italy) and colleagues in Thrombosis Research.

They assessed the rates of death and VTE recurrence at 24 months in 2119 registry patients with acute VTE. OF these, 1541 (72.7%) had deep vein thrombosis, 20 (9.7%) had pulmonary embolism, and 372 (17.6%) had both.

Data about mortality were available for 2021 (95.4%) patients and about recurrence for 1988 (93.8%) patients.

The authors found that 167 patients died during the follow-up period of 24 months.

Multivariate analysis showed that the presence of cancer, long-term heparin treatment, in-hospital management of VTE, and ileo-caval thrombosis were independent predictors for 24-month mortality, at age-adjusted hazard ratios (HRs) of 7.2, 2.5, 2.0, and 1.7, respectively.

Overall, 124 patients had a VTE occurrence during follow up. Multivariate analysis showed that in-hospital management of VTE and male gender were independent predictors for recurrent VTE, at HRs of 1.8 and 1.7, respectively.

Cancer showed a trend toward an increased risk for VTE recurrence, at an HR of 1.6.

"The observation that in-hospital management was found as [an] independent risk factor for death may reflect the worsen[ed] clinical condition of patients admitted in hospital in comparison with patients managed as outpatients," comment the authors.

MedWire ( is an independent clinical news service provided by Springer Healthcare Limited. © Springer Healthcare Ltd; 2012

By Piriya Mahendra

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