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26-05-2010 | Cardiology | Article

DVT link to peripheral venous disease suggested


Free abstract

MedWire News: Risk factors for deep vein thrombosis (DVT), such as D-dimer and the factor (F)V Leiden thrombopholic mutation, are common in patients with severe peripheral venous disease, US researchers report.

“The findings of this study support a hypothesis that some portion of chronic venous disease in the general population is due to previous unrecognized DVT,” suggest Mary Cushman (University of Vermont, Colchester) and co-workers in the Journal of Thrombosis and Haemostasis.

Noting that clinically silent DVT is common, the team hypothesized that this could lead to post-thrombotic syndrome symptoms that may be mistaken for chronic venous disease.

To investigate further, the researchers conducted a case–control study with 308 patients with four different levels of peripheral venous disease severity and 346 age-, race-, and gender-matched individuals without venous disease.

After adjusting for age, obesity and family history of leg ulcers, peripheral venous disease patients were more likely to have elevated FVIII, von Willebrand factor, and D-dimer than controls, and were more likely to carry the FV Leiden mutation.

The odds ratios for these venous thrombosis hemostatic risk factors were significant in patients with the two most severe levels of peripheral venous disease versus controls, at 2.0, 1.7, 2.7, and 2.3, respectively.

However, the thrombophilic mutation prothrombin G20210A was not significantly associated with venous peripheral disease.

“Results support a conclusion that there are shared risk factors between peripheral venous disease and venous thrombosis, and a hypothesis that for some patients, peripheral venous disease may be post-thrombotic syndrome due to previous unrecognized DVT,” Cushman et al conclude.

MedWire ( is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2010

By Lynda Williams

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