BIM inversely associated with stent thrombosis risk
MedWire News: People with a high body mass index (BMI) may have a lower risk for stent thrombosis than those with a low body mass index, Danish researchers report.
The reduced risk is only true for drug-eluting stents (DES), however; no such relationship was observed with bare metal stents (BMS), note Michelle Schmiegelow (Gentofte University Hospital, Copenhagen, Denmark) and colleagues.
The researchers investigated whether BMI predicts definite stent thrombosis in 5888 patients who underwent percutaneous coronary intervention (PCI) with implantation of at least one BMS or DES between 2000 and 2006. They also looked at whether any relationship observed was influenced by the stent type.
During a median follow-up period of 68 months, definite stent thrombosis occurred in 106 patients.
Definite stent thrombosis was defined as a myocardial infarction requiring acute or subacute PCI in the coronary segment with the index stent according to the Academic Research Consortium definition.
Multivariable Cox proportional-hazard models showed that, overall, each unit increase in BMI was associated with a significant 7% reduced risk for definite stent thrombosis.
However, further analysis showed that there was a significant interaction between stent type and BMI, such that each BMI unit increase was associated with a significant 14% reduced risk for definite stent thrombosis in patients with a DES. In contrast there was no significant relationship between BMI and the risk for definite stent thrombosis with a BMS.
The study data were presented at the 2011 European Society of Cardiology Congress in Paris, France.
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By Laura Dean