Gene polymorphism may interact with anthropometrics to affect MI risk
MedWire News: Spanish research suggests that anthropometric variables may interact with genetics to influence a person's risk for myocardial infarction (MI).
The team found that the C573T single nucleotide polymorphism of the angiotensin II type 1 (AT1) receptor gene was significantly more common in people who had survived MI than in healthy individuals.
But anthropometric variables including body mass index (BMI), waist-to-hip ratio, and waist and hip measurements appeared to affect the degree of risk it conferred.
The researchers say: "These results reflect the possible involvement of anthropometric variables, together with the genetic predisposition of the individual, in the development of cardiovascular diseases or, more specifically in this case, in the incidence of MI episodes."
Maria Morales-Suarez-Varela (University of Valencia) and co-workers note that the AT1 receptor mediates most of the biological effects of angiotensin II on the vascular wall, heart, adrenal gland, and kidney.
They studied the relationship between MI and the C573T and A1166C polymorphisms in the AT1 receptor gene in 174 patients who had survived myocardial infarction and 182 age- and gender-matched controls, with a mean age of 61.0 and 60.3 years, respectively.
The occurrence of the A1166C polymorphism did not significantly differ between the groups, the researchers report in the journal Cardiovascular Pathology.
However, there was a significant difference in the frequency of the C573T genotype between MI survivors and healthy control participants, with the CC genotype identified in 33.9% of MI patients versus 21.6% of healthy controls.
This difference was not only found when the CC, CT, and TT genotypes were analyzed separately but also when the genotypes CC and CT plus TT were grouped according to the dominant inheritance model.
Multivariate analysis indicated that the CC genotype was a risk factor for MI, with a crude odds ratio of 1.85 that remained similar, at 1.77, after adjusting for age, gender, and homeostasis model assessment.
But after adjusting for BMI, waist-to-hip ratio, and waist and hip measurements, the significant adjusted odds ratio increased and surpassed 2.
The researchers conclude: "The results of this case-control study indicate a role of the C573T polymorphism in the pathogenesis of vascular events due to its relationship with some risk factors."
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By Anita Wilkinson