Hypoadiponectinemia linked to LV diastolic dysfunction
MedWire News: Low levels of adiponectin are associated with left ventricular (LV) diastolic dysfunction in patients with known or suspected coronary artery disease (CAD), research suggests.
As reported in The American Journal of Cardiology, Hidekatsu Fukuta and colleagues, from the Nagoya City University Graduate School of Medical Sciences in Japan, examined plasma levels of adiponectin and leptin and their relationship with indices of LV diastolic and systolic function in 193 consecutive patients undergoing cardiac catheterization for CAD.
They analyzed: relaxation time constant (Tau); end-diastolic pressure (EDP); and ejection fraction (EF). The mean age of the patients was 69 years.
For all participants, mean adiponectin and leptin levels were 9.3 µg/ml and 7.5 ng/ml, respectively.
Adiponectin levels showed a significant negative association with Tau and EDP in both men and women, and these associations remained significant after adjustment for age, body mass index (BMI), heart rate, blood pressure, and CAD severity.
There were no significant correlations between adiponectin levels and EF, however, and no significant correlation was observed between leptin levels and Tau, EDP, or EF in either men or women.
These findings are "significant in showing the association of hypoadiponectinemia with invasively determined LV diastolic relaxation and pressure," explain Fukuta et al.
But "additional studies are necessary not only to elucidate the role of adiponectin in mediating the LV diastolic abnormalities, but also to examine whether adiponectin replacement might prevent the development of LV hypertrophy or diastolic dysfunction," they add.
Of note, the team observed that BMI and adiponectin levels correlated more strongly with the LV diastolic function indexes in women than men.
"The gender difference in the role of obesity and hypoadiponectinemia in mediating LV diastolic abnormalities merits additional investigation," conclude the researchers.
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By Nikki Withers