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30-04-2012 | Cardiology | Article

Combined perindopril, amlodipine pill improves BP control in ‘difficult’ hypertension


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MedWire News: A fixed-dose combination of perindopril and amlodipine significantly improves blood pressure (BP) control in patients with hard-to-treat hypertension, a study shows.

The findings were reported by Jacques Blacher (Université Paris-Descartes, France) at the 22nd European Meeting on Hypertension and Cardiovascular Protection in London, UK.

He told MedWire News: "In France, we consider that hypertensives who are treated by general practitioners (GPs) are at less cardiovascular risk than hypertensives who are taken care of by specialists.

"But in this survey we showed that those patients who don't see the specialist and are taken care of by the GP are at high risk and they need some medical [assistance]."

The AVANT'AGE study included 6256 patients (58% men, mean age 62.4 years). All patients were considered to have "difficult" hypertension, based on their GP's decision to modify chronic antihypertensive treatment because of not-at-goal BP (91%) and/or poor compliance or tolerance (46%).

All patients had their treatment regimen modified by the addition of a fixed combination of perindopril and amlodipine at one of four dosages: 5 mg/5 mg, 5 mg/10 mg, 10 mg/5 mg, or 10/10 mg, respectively.

Between baseline and 3-month follow-up, systolic BP fell by a mean of 20.3 mmHg (from 154.9 to 134.6 mmHg) while diastolic BP fell by a mean of 11.3 mmHg (from 90.2 to 78.9 mmHg) (p<0.001 for both).

Overall, 62.3% of patients achieved successful BP control (defined as 140/90 mmHg).

Reductions in systolic and diastolic BP were significantly less in obese patients and those with diabetes, as compared with patients without comorbidities (p<0.003 for both).

"In this open-label study, addition of a fixed combination of perindopril and amlodipine to BP regimen was efficient, in terms of BP control, for 62.3% of those patients with difficult hypertension," note the authors.

"We believe that using association of drugs in one pill could help in the control of high BP because compliance and perhaps tolerance is probably better," Blacher remarked.

MedWire ( is an independent clinical news service provided by Springer Healthcare Limited. © Springer Healthcare Ltd; 2012

By Piriya Mahendra

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