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15-08-2011 | Cardiology | Article

Diabetes, hypertension, dyslipidemia show clustered risk pattern


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MedWire News: Diabetes mellitus, hypertension, and dyslipidemia show a pattern of interrelated risk, where diagnosis of each condition affects the risk for developing the others, study results show.

Since all three have been linked previously to atherosclerotic cardiovascular disease, effort should be made to limit the development of further conditions when one has been diagnosed, say Michiaki Fukui (Kyoto Prefectural University of Medicine, Kyoto, Japan) and colleagues.

"Although the pathogenesis of the lifestyle-related diseases is not well understood, it is likely that the conditions represent a complex interplay between metabolic, genetic, and even environmental factors," they comment in the journal Diabetes Research and Clinical Practice.

Fukui and co-workers investigated risk factors for the simultaneous development of diabetes mellitus, hypertension, and dyslipidemia in a Japanese population. They reviewed data from 2530 men and 1774 women, who had at least one fasting blood examination between 1998 and 2003, and subsequently received at least one annual examination through to 2009.

Fukui et al report that, at baseline, diabetes mellitus, hypertension, and dyslipidemia were present in 151 (3.5%), 549 (12.8%), and 2042 (47.4%) of the participants, respectively.

During the course of follow-up, diabetes mellitus, hypertension, and dyslipidemia developed in 262, 1095 and 1240 subjects, respectively, yielding incidence rates of 77.4, 402.6, and 961.3 per 10,000 person-years, respectively.

Kaplan-Meier survival analyses showed that when hypertension or dyslipidemia was present at baseline, the hazard ratio (HR) for developing diabetes by 5 years was 3.01 or 2.11, respectively.

Similarly, presence of diabetes or hypertension at baseline was associated with a HR for developing dyslipidemia at year 5 of 1.17 or 1.20, respectively.

Lastly, when diabetes or dyslipidemia was present at baseline, the HR for developing hypertension at year 5 was 2.36 or 1.53, respectively.

"To our knowledge, this is the first study to investigate the risk factors for the development of diabetes mellitus, hypertension and dyslipidemia simultaneously in a community-based observational cohort study," Fukui et al conclude.

"Clustering of diabetes mellitus, hypertension and dyslipidemia is much more associated with CVD. Therefore, we should pay much attention to reduce the risk factors of diabetes mellitus, hypertension and dyslipidemia."

MedWire ( is an independent clinical news service provided by Springer Healthcare Limited. © Springer Healthcare Ltd; 2011

By Andrew Czyzewski

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