Pentosidine not linked to osteoporotic fracture link
MedWire News:Urinary pentosidine cannot be used to screen for osteoporotic fracture risk in postmenopausal women, say French researchers.
Pentosidine is an advanced glycation end product (AGE) caused by a spontaneous interaction between arginine and lysine amino acids and free sugars, levels of which increase with age in the body, especially in tissues with low turnover, explain Evelyne Gineyts and co-authors from Hôpital Edouard Herriot in Lyon.
Previously excessive pentosidine in cortical and trabecular bone has been linked to impaired bone quality in osteoporotic patients with hip fracture, and elevated serum concentrations have been identified in osteoporotic patients compared with healthy individuals.
Hypothesizing that urinary pentosidine could be used to identify postmenopausal women at risk for osteoporotic fracture, Gineyts et al measured levels in 396 healthy women aged an average of 63.3 years.
The women were followed-up for clinical fracture at 4-year intervals for an average of 10 years, during which time 28 women experienced vertebral and 60 women experienced peripheral fractures.
Analysis showed that women in the highest quartile (mean 157.2 pmol/mg) for pentosidine had a significantly increased risk for fracture compared with those in the lowest quartile (mean 80.8 pmol/mg), with a hazard ratio of 1.55.
However, this risk was no longer significantly increased, after adjusting for age, total hip bone mineral density, and prevalent fracture.
“Pentosidine appears to be a marker of frailty reflecting health, nutritional state, and renal impairment which is significantly associated to aging,” the team concludes in the journal Osteoporosis International.
They add: “Its measurement could provide some information concerning mechanisms leading to bone fragility but may be of limited clinical interest in the assessment of fracture risk.”
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By Lynda Williams