Lipid profile not linked to BMD in Korean women
MedWire News: An atherogenic lipid profile is not associated with bone mineral density (BMD) in pre- or postmenopausal Korean women, show the results of a large study.
The research team investigated the association between lipid profile and BMD because previous studies have reported conflicting results.
Although overall lipid profile did not strongly correlate with BMD, there was a weak positive association between high-density lipoprotein (HDL) cholesterol and BMD at the lumbar spine, note Chan Soo Shin (Seoul National University College of Medicine, Republic of Korea) and co-researchers.
They reviewed data from 4613 premenopausal (mean age 43.5 years) and 2661 postmenopausal women (mean age 58.6 years) who had their serum glucose, total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, HDL cholesterol, and triglyceride (TG) levels measured between October 2003 and October 2005.
At the same time, the women also underwent BMD testing at the lumbar spine, total hip, femoral neck, and trochanter.
Overall, 357 (4.9%) women had osteoporosis: 24 were premenopausal and 333 were postmenopausal.
In multivariate analyses, adjusted for potential confounders including age, body mass index, and age at menarche, the only lipid that was associated with BMD was HDL cholesterol, where there was a weak positive correlation (correlation coefficient=0.05) at the lumbar spine in postmenopausal women only.
Shin and co-authors remark that the contradictory results reported in previous studies may be due to variable sizes of study populations, ranging from hundreds to thousands, and heterogeneous eligibility criteria and analytical methods.
"It is interesting to note that studies with larger sample sizes were more likely to show no association between lipid profiles and BMD," they say.
Writing in the journal Calcified Tissue International, they conclude that their results do not support the hypothesis that an atherogenic lipid profile is associated with osteoporosis.
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By Laura Dean