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23-12-2009 | Bone health | Article

IOF quality of life questionnaire for wrist fracture reliable and responsive


Free abstract

MedWire News: The 12-question quality of life questionnaire for wrist fracture developed by the International Osteoporosis Foundation (IOF) is both reliable and responsive, giving an accurate reflection of patient status over time, concludes a study by an international collaboration of researchers.

Wrist fracture is a major osteoporotic fracture, causes pain and acute loss of physical function, and has an impact on social and emotional function.

Paul Lips (VU University Medical Center, Amsterdam) and co-workers examined 105 patients with a recent wrist fracture and 74 gender- and age- matched controls. The IOF questionnaire was administered as soon as possible after the fracture, and again after 6 weeks, 3 months, 6 months and 1 year. Test–retest reproducibility, internal consistency, and sensitivity to change were assessed.

The IOF questionnaire asked patients about pain, pins and needles, and stiffness related to their fracture. They were also asked if the deformity caused by the fracture disturbed them, if they could do everyday activities such as washing hair, turning a key or lid, type or write, or drive a car or bicycle. They were also if the injury had interfered with their activities of the previous week, if they required help from friends or relatives due to the fracture; and if their quality of life had declined in the previous 3 months due to the fracture.

The researchers found that the IOF-wrist fracture questionnaire domain scores showed significant improvement after 3 and 6 months, and some improvement from 6 months up to 1 year. The sensitivity to change was significantly higher for the IOF-wrist fracture total score than for the osteoporosis-specific Qualeffo-41 and generic EQ-5D quality of life forms.

“The IOF-wrist fracture questionnaire appears to be a reliable and responsive quality of life questionnaire, showing sufficient repeatability, high internal consistency and adequate sensitivity to change,” Lips et al write.

”It is ready for use in patients with wrist fracture, preferably in combination with Qualeffo-41 for overall evaluation of quality of life with regard to osteoporosis,” they conclude.

MedWire ( is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2009

By Tony Kirby

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