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22-12-2016 | Alzheimer's disease | News | Article

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Protein in urine linked to dementia risk

medwireNews: Albuminuria is modestly associated with the risk for dementia, researchers report in findings supporting the view that cognitive decline and renal dysfunction may be linked.

Kay Deckers (Maastricht University, the Netherlands) and colleagues carried out a systematic review of 22 prospective studies examining associations between different markers of renal dysfunction and cognitive decline.

Pooled analysis of 27,805 individuals in five studies assessing albuminuria showed a 35% increased risk of cognitive impairment or dementia in affected patients compared with their peers without the condition.

The findings for low levels of estimated glomerular filtration rate were mixed, however, with separate meta-analyses for different levels failing to yield significant results, possibly due to heterogeneity among studies, suggest the researchers in Neurology.

Differences in study methodology meant meta-analyses could not be done for cystatin C, serum creatinine, or creatinine clearance, although the authors report that there was “tentative evidence” of an association between dementia and the latter two markers.

“Chronic kidney disease and dementia share many factors, such as high blood pressure, diabetes and high cholesterol, and both show similar effects on the brain, so they may have shared vascular factors or there may even be a direct effect on the brain from kidney problems,” Decker said in a press statement.

By Lucy Piper

medwireNews is an independent medical news service provided by Springer Healthcare Limited. © Springer Healthcare Ltd; 2016

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