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Motor neuron diseases

20-12-2018 | Motor neuron diseases | News | Article

Cannabinoid spray shows anti-spasticity efficacy in motor neuron disease

The oromucosal cannabinoid spray nabiximols has had a positive effect on spasticity symptoms in patients with motor neuron disease in a proof-of-concept trial.

Source:

Lancet Neurol 2018; doi:10.1016/ S1474-4422(18)30406-X

Lancet Neurol 2018; doi:10.1016/ S1474-4422(18)30493-9

11-04-2016 | Neurology | News | Article

News in brief

Prognostic markers expanded for AD, ALS

Two studies expand the range of putative prognostic markers for neurological disease, with creatinine kinase found to be prognostic in amyotrophic lateral sclerosis and neurogranin offering diagnostic and prognostic potential in Alzheimer’s disease.

29-02-2016 | Motor neuron diseases | News | Article

Cardiac drug combats muscle cramps in ALS

A phase II study shows that the sodium channel blocker mexiletine has no specific safety concerns in patients with amyotrophic lateral sclerosis and, moreover, markedly reduces muscle cramps.

Source:

Neurology 2016; Advance online publication

17-12-2015 | Motor neuron diseases | News | Article

Pauses and reversals ‘not uncommon’ in ALS progression

Patients with amyotrophic lateral sclerosis often have periods of stable disease, with some even experiencing brief improvements, shows analysis of the PRO-ACT database.

Source:

Neurology 2015; Advance online publication

09-10-2015 | Motor neuron diseases | News | Article

Role for endogenous retrovirus proposed in ALS pathogenesis

Expression of the human endogenous retrovirus-K is upregulated in some patients with sporadic amyotrophic lateral sclerosis and causes degeneration of motor neurons when overexpressed in mice, research shows.

Source:

Sci Transl Med 2015; 7: 307ra153

09-09-2015 | Motor neuron diseases | News | Article

Cortical hyperexcitability has a driving role in ALS

Cortical hyperexcitability is an intrinsic feature of amyotrophic lateral sclerosis symptoms in patients carrying the chromosome 9 open reading frame 72 gene hexanucleotide repeat expansion, show study findings.

Source:

JAMA Neurol 2015; Advance online publication

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