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Pharmacology

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23-07-2013 | Rheumatology | Article

Intensive therapy pays employment dividends in rheumatoid arthritis

Biologic-based combination therapy for patients with rheumatoid arthritis is no more effective in reducing work loss than conventional combination therapy, despite better radiologic outcomes, shows a secondary analysis of a randomized trial.

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JAMA Intern Med 2013; Advance online publication

30-06-2013 | Cardiology | Article

Antihypertensive adherence sinks under depression

The onset of depression increases the risk for nonadherence to antihypertensive medication, but only among men, research published in the Journal of Hypertension suggests.

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J Hypertens 2013; 31: 1362–1363, 1477–1484

18-06-2013 | Respiratory | Article

High-dose steroids for COPD raise diabetes complication risk

Australian research shows that in older patients with chronic obstructive pulmonary disease and comorbid diabetes, high-dose corticosteroids are associated with an increased risk for diabetes-related complications, regardless of how they are administered.

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Diabetes Care 2013; Advance online publication

05-06-2013 | General practice | Article

Diuretic treatment linked to COPD steroid efficacy

Research shows that patients with chronic obstructive pulmonary disease benefit the most from the addition of an inhaled corticosteroid to their bronchodilator therapy if they are receiving diuretics or show significant bronchodilator reversibility.

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BMJ Open 2013; 3: e001838

03-06-2013 | Respiratory | Article

Nicotine-induced changes alter EGFR-TKI efficacy

Japanese scientists have uncovered a mechanism by which smoking reduces the efficacy of epidermal growth factor receptor tyrosine kinase inhibitor therapy in patients with lung cancer.

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J Thorac Oncol 2013; 8: 719–725

03-06-2013 | Respiratory | Article

HER2 screening recommended for lung adenocarcinoma patients

Researchers highlight the importance of testing for HER2 mutations in patients with non-small-cell lung cancer, adding to evidence that supports the use of HER2-targeted drugs in this population.

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J Clin Oncol 2013; Advance online publication

29-05-2013 | Respiratory | Article

nab-paclitaxel promising for Japanese NSCLC patients

Phase III trial results support the use of albumin-bound paclitaxel plus carboplatin as a first-line treatment for Japanese patients with advanced non-small-cell lung cancer.

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Lung Cancer 2013; Advance online publication

29-05-2013 | Respiratory | Article

Community pharmacists help optimize COPD treatment

Data from Japan show that the introduction of an educational program allowing community pharmacists to deliver inhaler technique training to patients with chronic obstructive pulmonary disease led to improved adherence and outcomes.

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Int J Chron Obstruct Pulmon Dis 2013; 8: 239–244

29-05-2013 | Respiratory | Article

Selective ALK inhibitor shows NSCLC promise

Preliminary trial results suggest that a novel, highly selective ALK inhibitor may be effective for the treatment of advanced non-small-cell lung cancer in Japanese patients with the ALK rearrangement.

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Lancet Oncol 2013; Advance online publication

27-05-2013 | Immunology | Article

New Samter’s syndrome classification proposed

Turkish researchers have developed a classification system for patients with hypersensitivity to non-steroidal anti-inflammatory drugs.

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Respir Med 2013; Advance online publication

07-05-2013 | Respiratory | Article

Hsp90 inhibitor shows NSCLC promise

Treatment with a heatshock protein 90 inhibitor may induce loss of EML4-AKL expression in non-small cell lung cancer cells, preliminary results suggest.

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Cancer Discov 2013; 3: 430–443

29-04-2013 | Rheumatology | Article

Rituximab joint protective benefits capped

Study findings may help guide rituximab dosing regimens for patients with rheumatoid arthritis.

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Rheumatol 2013; Advance online publication

29-04-2013 | Pathology | Article

Measles outbreak prompts national vaccination catch-up program in UK

Health officials in the UK have announced a national catch-up program to target 10–16 year olds who did not receive the combined measles, mumps, and rubella vaccination in early childhood due to fears about links with autism.

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Public Health England, Public Health Wales

28-04-2013 | Internal medicine | Article

IL-1 antagonist relieves dry eyes

Clinical trial results point to a role for interleukin-1 targeted agents for the treatment of dry eye disease associated with meibomian gland dysfunction.

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JAMA Ophthalmol 2013; Advance online publication

28-04-2013 | Gynaecology | Article

Autism linked to epilepsy drug use in pregnancy

Children born to mothers who take valproate during pregnancy are at increased risk for developing autism compared with children of women who did not take the epilepsy drug, Danish research shows.

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JAMA 2013; 309: 1696–1703

25-04-2013 | Pharmacology | Article

Drug alerts have variable impact on prescribing habits

Direct communication with healthcare professionals, in the form of so-called “Dear doctor” letters, can be effective in reducing inappropriate and unsafe use of medicines, Dutch scientists believe.

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Clin Pharm Ther 2013; Advance online publication

25-04-2013 | Surgery | Article

Osteomyelitis guidelines push pediatric care

US clinicians have demonstrated the benefits of multidisciplinary evidence-based guidelines for the treatment of children with osteomyelitis.

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J Bone Joint SurgAm 2013; 95: 686–693

24-04-2013 | Cardiology | Article

Beta blockade aids select surgery patients

Research supports the use of perioperative beta blockade in patients with cardiovascular risk factors undergoing nonvascular procedures, finding this treatment to significantly improve short-term survival.

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JAMA 2013; 309: 1704–1713

24-04-2013 | Gastroenterology | Article

Surgery extends life for metastatic colorectal cancer patients

Individuals with colorectal cancer that has metastasized to the liver or lung live longer after curative surgery plus chemotherapy than their counterparts who receive palliative chemotherapy alone, report researchers.

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Br J Cancer 2013; 108: 1425–1431

23-04-2013 | Gastroenterology | Article

Crohn’s permanent stoma rates plummet in post-biologic era

Permanent stoma creation in patients with extensive Crohn’s disease has fallen to a third of its previous rate following the advent of biologic therapy, research shows.

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Colorectal Dis 2013; Advance online publication