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Rheumatology

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02-08-2019 | Rheumatology | News | Article

Machine learning shows promise for predicting TNF inhibitor response

A machine-learning model may help to predict which rheumatoid arthritis patients are likely to respond to treatment with TNF inhibitors, researchers report.

31-07-2019 | Rheumatology | News | Article

Predictors of successful biologic discontinuation in RA patients described

A systematic review has identified several factors predicting successful discontinuation of biologic DMARDs in people with rheumatoid arthritis, including low disease activity and good physical function.

30-07-2019 | Rheumatology | News | Article

Abatacept fails to improve skin disease in SSc trial

Findings from the phase II ASSET trial suggest that patients with diffuse cutaneous systemic sclerosis who are treated with abatacept do not experience significantly greater improvements in skin disease than those given placebo.

29-07-2019 | Rheumatology | News

FDA gives nod to adalimumab-bwwd

Click through for more information on the approval

29-07-2019 | Rheumatology | News | Article

FDA adds boxed warnings to tofacitinib label

Click through for further details on the new warnings

26-07-2019 | Rheumatology | News | Article

Asbestos, silica exposure linked to RA risk

Male workers with occupational exposure to asbestos or silica may have an elevated risk for developing rheumatoid arthritis, Swedish researchers report.

25-07-2019 | Rheumatology | News | Article

FINCH 2: Further evidence for filgotinib as a treatment option for RA

Rheumatoid arthritis (RA) patients with an inadequate response or intolerance to biologic DMARDs who are treated with the selective JAK1 inhibitor filgotinib are more likely to achieve a clinical response than those given placebo, phase III trial results suggest.

24-07-2019 | Rheumatology | News | Article

EULAR issues updated guidance for managing large vessel vasculitis

EULAR has released updated recommendations for the management of large vessel vasculitis, including giant cell arteritis and Takayasu arteritis.

24-07-2019 | Rheumatology | News | Article

Success of etanercept withdrawal linked to pre-withdrawal remission status

The likelihood of maintaining remission following etanercept withdrawal is highest among rheumatoid arthritis patients with the greatest degree of remission prior to the start of withdrawal and decreases with decreasing remission status, research shows.

23-07-2019 | Rheumatology | News | Article

Low IGF1 levels predict CV risk in RA patients

Low levels of insulin-like growth factor 1 are associated with increased rates of cardiovascular events among women with rheumatoid arthritis, researchers report.

22-07-2019 | Rheumatology | News | Article

Partial knee replacement recommended for medial compartment osteoarthritis

Partial knee replacement is more cost-effective than total knee replacement over 5 years for patients with late-stage isolated medial compartment osteoarthritis of the knee, show results of the TOPKAT trial published in The Lancet.

19-07-2019 | Rheumatology | News | Article

Genetic loci influencing asymptomatic hyperuricemia to gout progression identified

A Japanese genome-wide association study has identified novel genetic loci associated with the susceptibility of gout in individuals with asymptomatic hyperuricemia.

18-07-2019 | Rheumatology | News | Article

Surrogate randomization technique enables triple biologic comparison

Estimated remission and retention rates do not differ significantly among patients with rheumatoid arthritis treated with either certolizumab pegol, abatacept, or biosimilar infliximab, show the results of a surrogate randomized controlled trial.

17-07-2019 | Rheumatology | News | Article

Mild tapering of TNF inhibitors may be appropriate in axSpA

Real-world study results suggest that mild tapering of tumor necrosis factor inhibitors does not influence the probability of achieving inactive disease among patients with axial spondyloarthritis.

15-07-2019 | Rheumatology | News | Article

Vitamin D has potential benefits for people with osteoarthritis

Vitamin D intake is inversely associated with cartilage degeneration among patients with osteoarthritis, and supplementation may have a protective effect, suggests an analysis of data from the Osteoarthritis Initiative.

12-07-2019 | Rheumatology | News | Article

SELECT COMPARE: Upadacitinib outperforms placebo and adalimumab in RA

Rheumatoid arthritis (RA) patients treated with the JAK1 selective inhibitor upadacitinib experience greater improvement in the signs and symptoms of disease than those given placebo or adalimumab, indicate findings from the SELECT COMPARE trial.

11-07-2019 | Rheumatology | News | Article

Biologic therapy has paved the way for improved outcomes in JIA

The biologic treatment era has led to “remarkable prognostic improvement,” relative to the methotrexate era, for children with juvenile idiopathic arthritis, show data reported in Arthritis Research & Therapy.

10-07-2019 | Rheumatology | News | Article

Biologic treatment may improve control of PsA-related bone disease

Psoriatic arthritis patients treated with biologic DMARDs have higher bone mass and strength than those not receiving DMARD treatment, suggest findings from a cross-sectional study.

09-07-2019 | Rheumatology | News | Article

Pregnancy outcomes improving for women with SLE

In the past two decades pregnancy outcomes, including in-hospital maternal mortality, have improved among women with systemic lupus erythematosus, but further improvements are needed to reduce risks further, US research shows.

08-07-2019 | Rheumatology | News | Article

RA genetic risk linked to IQ, hyperactivity during childhood

Genetic liability for rheumatoid arthritis is associated with lower IQ and symptoms of hyperactivity and inattention during childhood and adolescence, supporting a link between genetic risk for the condition and neural phenotypes, UK researchers report.

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