Rheumatology

The majority of people with anti-CCP2 antibodies and musculoskeletal symptoms without clinical synovitis have a period of subclinical synovitis that precedes inflammatory arthritis, research shows.

Findings from a phase 2 proof-of-concept study suggest that abatacept may warrant further investigation as a treatment option for certain subsets of people with IgG4-related disease.

Pain affects almost nine in every 10 people with systemic sclerosis, with multiple disease-related factors potentially contributing to pain intensity, researchers report.

A meta-analysis carried out by the COVID-19 Global Rheumatology Alliance suggests that people with rheumatic and musculoskeletal diseases have a higher risk for SARS-CoV-2 infection and mortality than the general population.

People with rheumatic and musculoskeletal diseases who experience breakthrough SARS-CoV-2 infection after vaccination have lower rates of poor COVID-19 outcomes than their unvaccinated counterparts, researchers report.

Delaying the third dose of vaccines against SARS-CoV-2 until B-cell repopulation may warrant investigation as a strategy to improve response rates among rituximab-treated patients, suggest findings from a small study.

Overweight or obese people with knee osteoarthritis may benefit from a diet- and exercise-focused telehealth intervention, which researchers have shown can improve pain and function over 6 months.

Intra-articular injections of platelet-rich plasma do not reduce knee pain or disease progression for people with symptomatic mild-to-moderate radiographic medial knee osteoarthritis, suggest findings from a randomized controlled trial.

A retrospective cohort study shows that patients with systemic lupus erythematosus have similar kidney failure outcomes to non-SLE patients, but a higher risk for death after transplantation.

Findings from a meta-analysis suggest that bisphosphonate therapy for osteoporosis is most likely to benefit postmenopausal women who have a life expectancy of more than 12 months.

Human leucocyte antigen-DRB1*15 haplotypes are strongly associated with delayed drug reaction with eosinophilia and systemic symptoms in people receiving IL-1 or IL-6 inhibitors for Still’s disease, research suggests.

Swollen joints are more likely to be associated with ultrasound-confirmed synovitis than tender joints among DMARD-naïve individuals with early psoriatic arthritis, research suggests.

Click through for details on this announcement

Individuals with rheumatoid arthritis, ankylosing spondylitis, or psoriatic arthritis have almost comparable survival rates to those of the general population, Greek study findings indicate.

Musculoskeletal inflammation and damage is one of several factors that could help predict psoriatic arthritis development among patients with psoriasis, suggest results of a meta-analysis and systematic review.

Telemedicine might be equally effective to standard in-person follow-up for maintaining disease control in systemic lupus erythematosus patients in the short term, with good levels of patient satisfaction, suggests a 6-month randomized controlled trial.

A learning collaborative has improved adherence to a treat-to-target approach for patients with rheumatoid arthritis irrespective of whether patients are seen virtually or face to face, show findings from an analysis of 18 US clinics.

Tofacitinib is not associated with a higher risk for cardiovascular outcomes than TNF inhibitors in the overall population of people with rheumatoid arthritis, suggest findings from a US database study.

Response to treatment for psoriatic arthritis may be impaired for people with obesity, particularly if they are starting a TNF inhibitor, research suggests.

Patients with autoimmune or inflammatory rheumatic diseases may be at increased risk for breakthrough SARS-CoV-2 infection following vaccination, suggests research from two separate cohorts.