Patients at high genetic risk of bipolar disorder may be able to avert onset of the condition due to natural adaptive neuroplasticity that allows the brain to compensate for underlying network dysfunction associated with the condition, researchers report.
Combining lamotrigine with quetiapine improves the treatment of depressive symptoms in patients with bipolar disorder, with the benefits maintained for at least a year, show findings from the CEQUEL trial.
Concomitant manic symptoms and panic attacks are the strongest predictors of an impending switch to mania among patients with bipolar disorder who are currently depressed, shows analysis of the STEP-BD study.
Depressive, anxiety and behavioural disorders may be important preceding clinical features in the onset of bipolar disorder, with the potential for targeted preventive care of at-risk individuals, study findings suggest.
Atypical features are prevalent in all subtypes of bipolar disorder, a Chinese survey published in Neuroscience Bulletin, shows, and are associated with the use of antidepressant medication in patients with mixed stage and remission subtypes.