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08-07-2019 | Rheumatology | News | Article

RA genetic risk linked to IQ, hyperactivity during childhood

Genetic liability for rheumatoid arthritis is associated with lower IQ and symptoms of hyperactivity and inattention during childhood and adolescence, supporting a link between genetic risk for the condition and neural phenotypes, UK researchers report.

03-06-2019 | Gastrointestinal cancer | Video

ASCO 2019: Olaparib maintenance improves BRCA1/2-positive pancreatic cancer outcomes

Hedy Kindler presents the phase III POLO trial of maintenance therapy with the PARP inhibitor olaparib in metastatic pancreatic cancer patients harbouring germline mutations in BRCA1 or BRCA2 (3:47).

22-01-2019 | Oncology | News | Article

Mutational load predicts immunotherapy response across most tumor types

Tumor mutational burden could be a cross-tumor predictive biomarker of immunotherapy, say US researchers who found an association between mutational load and survival across a wide range of malignancies treated with immune checkpoint inhibitors.

16-01-2019 | Prostate cancer | News | Article

Germline BRCA2 mutations impact mCRPC survival

Germline mutations in the BRCA2 gene, but not other DNA damage repair genes, are associated with poorer outcomes among patients with metastatic castration-resistant prostate cancer, study findings indicate.

11-01-2019 | Oncology | News | Article

COMT gene modifies chemopreventive effects of vitamin E

Vitamin E supplementation may reduce the risk for cancer but only in individuals harboring a particular allele of the catechol-O-methyltransferase gene, suggests an analysis of two randomized trials.

20-12-2018 | Asthma | News | Article

Genetic variants linked to moderate-to-severe asthma susceptibility

A genome-wide association study has identified novel genetic variants associated with the risk of developing moderate-to-severe asthma, a substantial proportion of which are also associated with mild asthma susceptibility.

19-09-2018 | Oncology | News | Article

Persistent mutations post-transplant predict MDS disease progression

Persistent disease-associated mutations detected in the bone marrow 30 days after stem cell transplantation are associated with an increased risk for disease progression among patients with myelodysplastic syndrome, research shows.

23-08-2018 | Oncology | News | Article

New molecular target classification system could aid treatment decision making

The ESMO Translational Research and Precision Medicine Working Group has proposed a classification system that orders the value of molecular aberrations as oncologic clinical targets based on the supporting evidence available.

09-08-2018 | Non-small-cell lung cancer | News | Article

Broad-based genomic screening benefits questioned for advanced NSCLC

Most patients being treated in the community setting for advanced nonsquamous non-small-cell lung cancer do not benefit from the use of broad-based genomic sequencing, suggests a study comparing this approach with routine testing for only epidermal growth factor receptor and anaplastic lymphoma kinase alterations.

08-08-2018 | Non-small-cell lung cancer | News | Article

Molecular mechanisms of acquired osimertinib resistance explored

An analysis of patients with T790M-positive, advanced non-small-cell lung cancer who developed resistance to osimertinib points to heterogeneous underlying molecular mechanisms.

30-07-2018 | Breast cancer | News | Article

TGFB1 gene key determinant of breast fibrosis risk

Carriers of the C−509T allele in the transforming growth factor ß 1 gene have a significantly increased risk for late breast fibrosis following breast-conserving surgery and whole-breast irradiation for stage 0 to IIA breast cancer, researchers report.

06-06-2018 | Genetics | Video

Matching treatment to molecular alterations in tumors has an IMPACT on survival

Apostolia Tsimberidou discusses the findings of the IMPACT study, looking at the survival benefits of matching targeted treatments to the genetic alterations of tumors across multiple cancer types (7:56).

11-05-2018 | Breast cancer | News | Article

Germline BRCA status may influence advanced TNBC chemotherapy choice

Testing for BRCA1 and BRCA2 mutations could inform the choice of chemotherapeutic agent in women with advanced triple-negative breast cancer, suggest the results of the TNT trial.

11-04-2018 | Non-small-cell lung cancer | News | Article

Concomitant mutations linked to poorer response in EGFR mutation-positive NSCLC

In patients with epidermal growth factor receptor-mutated non-small-cell lung cancer, the presence of concomitant mutations in other cancer-related genes is associated with worse outcomes in response to EGFR tyrosine kinase inhibitors, Chinese research suggests.

11-04-2018 | Leukaemia | News | Article

Molecular minimal residual disease predicts poor outcome in AML

The presence of molecular minimal residual disease, identified by next-generation targeted sequencing, is associated with a significantly increased risk for relapse or death in patients with acute myeloid leukemia, study findings indicate.

12-03-2018 | Oncology | News | Article

Telephone disclosure may be a valid option for revealing cancer genetic test results

For individuals who have undergone germline genetic testing, receiving the results via telephone could be a valid alternative to in-person disclosure, trial findings suggest.

18-01-2018 | Breast cancer | News | Article

Breast cancer survival not linked to BRCA status in young women

BRCA mutation status does not impact survival in young women with breast cancer, results of a large prospective cohort study show.

12-01-2018 | Prostate cancer | News | Article

Genetic risk model could guide prostate cancer screening

A polygenic hazard score that evaluates an individual’s age-related risk for developing prostate cancer could help guide personalized decision making about prostate-specific antigen screening, say researchers.

16-11-2017 | Colorectal cancer | News | Article

Mismatch repair deficiency testing underused for CRC patients in USA

Researchers have warned that underuse of mismatch repair deficiency testing “is a persistent and pervasive problem” in the USA, even among young adults with colorectal cancer where its use is unequivocally recommended.

15-08-2017 | Neuro-oncology | News | Article

Genetic testing recommended for schwannoma, meningioma in young patients

A high proportion of children and young adults with apparently solitary schwannoma or meningioma have mutations in known constitutional tumor predisposition genes, study data show.

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